BDBM14032 4-(1-ethyl-1H-imidazo[4,5-c]pyridin-2-yl)-1,2,5-oxadiazol-3-amine::4-{1-ethyl-1H-imidazo[4,5-c]pyridin-2-yl}-1,2,5-oxadiazol-3-amine::Aminofurazanyl-azabenzimidazole 1::CHEMBL189657

SMILES CCn1c(nc2cnccc12)-c1nonc1N

InChI Key InChIKey=UGHABJRZQKZAHP-UHFFFAOYSA-N

Data  14 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 14032   

TargetRho-associated protein kinase 1(Human)
Glaxosmithkline

LigandPNGBDBM14032(4-(1-ethyl-1H-imidazo[4,5-c]pyridin-2-yl)-1,2,5-ox...)
Affinity DataIC50: 19nMpH: 7.4 T: 2°CAssay Description:The assay of Rock-1 activity involved incubation with peptide substrate and ATP/[gamma-33P] ATP, the subsequent incorporation of 33P into the peptid...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2007
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM14032(4-(1-ethyl-1H-imidazo[4,5-c]pyridin-2-yl)-1,2,5-ox...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human ROCK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Glaxosmithkline

LigandPNGBDBM14032(4-(1-ethyl-1H-imidazo[4,5-c]pyridin-2-yl)-1,2,5-ox...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human recombinant N-terminal his-tagged ROCK1 (3-543) expressed in baculovirus infected Sf9 cells using Biotin-Ahx-AKRRLSSLRA-CONH2 sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-5(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM14032(4-(1-ethyl-1H-imidazo[4,5-c]pyridin-2-yl)-1,2,5-ox...)
Affinity DataIC50: 3nMAssay Description:Inhibitory concentration exhibited towards MSK-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM14032(4-(1-ethyl-1H-imidazo[4,5-c]pyridin-2-yl)-1,2,5-ox...)
Affinity DataIC50: 110nMAssay Description:Inhibitory concentration against selected kinase DYRK1-alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Glaxosmithkline

LigandPNGBDBM14032(4-(1-ethyl-1H-imidazo[4,5-c]pyridin-2-yl)-1,2,5-ox...)
Affinity DataIC50: 13nMAssay Description:Inhibitory concentration against selected kinase ROCK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM14032(4-(1-ethyl-1H-imidazo[4,5-c]pyridin-2-yl)-1,2,5-ox...)
Affinity DataIC50: 169nMAssay Description:Inhibitory concentration against selected kinase CDK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase beta-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM14032(4-(1-ethyl-1H-imidazo[4,5-c]pyridin-2-yl)-1,2,5-ox...)
Affinity DataIC50: 70nMAssay Description:Inhibitory concentration against selected kinase p70S6KMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-5(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM14032(4-(1-ethyl-1H-imidazo[4,5-c]pyridin-2-yl)-1,2,5-ox...)
Affinity DataIC50: 3nMAssay Description:Inhibitory concentration against MSK-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-5(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM14032(4-(1-ethyl-1H-imidazo[4,5-c]pyridin-2-yl)-1,2,5-ox...)
Affinity DataIC50: 3nMAssay Description:Inhibition of MSK-1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetRibosomal protein S6 kinase alpha-1(Human)
Treventis

Curated by ChEMBL
LigandPNGBDBM14032(4-(1-ethyl-1H-imidazo[4,5-c]pyridin-2-yl)-1,2,5-ox...)
Affinity DataIC50: 24nMAssay Description:Inhibition of RSK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetRho-associated protein kinase 1(Human)
Glaxosmithkline

LigandPNGBDBM14032(4-(1-ethyl-1H-imidazo[4,5-c]pyridin-2-yl)-1,2,5-ox...)
Affinity DataIC50: 13nMAssay Description:Inhibition of ROCK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetCyclin-dependent kinase 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM14032(4-(1-ethyl-1H-imidazo[4,5-c]pyridin-2-yl)-1,2,5-ox...)
Affinity DataIC50: 169nMAssay Description:Inhibition of CDK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
LigandPNGBDBM14032(4-(1-ethyl-1H-imidazo[4,5-c]pyridin-2-yl)-1,2,5-ox...)
Affinity DataIC50: 110nMAssay Description:Inhibition of DYRK1A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed