BDBM13997 5-{3-[(1E)-3-[3-hydroxy-2-(methoxycarbonyl)phenoxy]prop-1-en-1-yl]phenyl}-4-(hydroxymethyl)-1,2-oxazole-3-carboxylic acid::Isoxazole carboxylic acid analog 8

SMILES COC(=O)c1c(O)cccc1OC\C=C\c1cccc(c1)-c1onc(C(O)=O)c1CO

InChI Key InChIKey=DQSRCEFDWMQCCV-UHFFFAOYSA-N

Data  3 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 13997   

TargetTyrosine-protein phosphatase non-receptor type 2(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM13997(5-{3-[(1E)-3-[3-hydroxy-2-(methoxycarbonyl)phenoxy...)
Affinity DataIC50: 1.92E+4nMAssay Description:Inhibition of TCPTP (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/29/2017
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM13997(5-{3-[(1E)-3-[3-hydroxy-2-(methoxycarbonyl)phenoxy...)
Affinity DataIC50: 920nMAssay Description:Inhibition of PTP1B (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/29/2017
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM13997(5-{3-[(1E)-3-[3-hydroxy-2-(methoxycarbonyl)phenoxy...)
Affinity DataKi:  0.920nMAssay Description:Inhibition of PTP1B (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
LigandPNGBDBM13997(5-{3-[(1E)-3-[3-hydroxy-2-(methoxycarbonyl)phenoxy...)
Affinity DataKi:  920nM ΔG°:  -8.15kcal/molepH: 7.5 T: 2°CAssay Description:The phosphatase activity resulted in the formation of the colored product p-nitrophenol, which was continuously monitored at 405 nm every 30 s for 15...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2007
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM13997(5-{3-[(1E)-3-[3-hydroxy-2-(methoxycarbonyl)phenoxy...)
Affinity DataKi:  1.92E+4nM ΔG°:  -6.37kcal/molepH: 7.5 T: 2°CAssay Description:The phosphatase activity resulted in the formation of the colored product p-nitrophenol, which was continuously monitored at 405 nm every 30 s for 15...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2007
Entry Details Article
PubMed