BDBM139376 US8889671, 5

SMILES C[C@@H]1CN2c3c(cc4c(c3F)onc4N5[C@H](COC5=O)C)CC6([C@H]2[C@@H](O1)C)C(=O)NC(=O)NC6=O

InChI Key InChIKey=ZSWMIFNWDQEXDT-UHFFFAOYSA-N

Data  3 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 139376   

TargetDNA gyrase subunit A(Escherichia coli (strain K12))
Astrazeneca

US Patent
LigandPNGBDBM139376(US8889671, 5)
Affinity DataIC50: 169nMpH: 7.5Assay Description:In a black, 384-well polystyrene assay plate, 30 microliters/well of 5 nM Escherichia coli DNA gyrase A/B tetramer and 130 micrograms/mL of topologic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/27/2015
Entry Details
Go to US Patent

TargetDNA gyrase subunit A/B(Staphylococcus aureus)
University of Cape Town

Curated by ChEMBL
LigandPNGBDBM139376(US8889671, 5)
Affinity DataIC50: 4.30E+3nMAssay Description:Inhibition of Staphylococcus aureus ATTC 25923 DNA gyraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetDNA gyrase subunit B(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
University of Cape Town

Curated by ChEMBL
LigandPNGBDBM139376(US8889671, 5)
Affinity DataIC50: 3.20E+4nMAssay Description:Inhibition of Mycobacterium tuberculosis H37Rv DNA gyraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed