BDBM13589 (4-carbamimidoyl-phenylamino)-[3-ethoxy-2-fluoro-5-(tetrahydro-furan-3- yloxy)-phenyl]-acetic acid::2-[(4-carbamimidoylphenyl)amino]-2-[5-ethoxy-2-fluoro-3-(oxolan-3-yloxy)phenyl]acetic acid::phenylglycine derivative 4

SMILES [H]/N=C(\c1ccc(cc1)N[C@H](c2cc(cc(c2F)O[C@@H]3CCOC3)OCC)C(=O)O)/N

InChI Key InChIKey=PGYOHIAQCFZQDK-UHFFFAOYSA-N

Data  4 KI

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 13589   

TargetCoagulation factor VII(Human)
F. Hoffmann-La Roche

LigandPNGBDBM13589(2-[(4-carbamimidoylphenyl)amino]-2-[5-ethoxy-2-flu...)
Affinity DataKi:  88nM ΔG°:  -9.52kcal/molepH: 7.8 T: 2°CAssay Description:The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/5/2007
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCoagulation factor X(Human)
F. Hoffmann-La Roche

LigandPNGBDBM13589(2-[(4-carbamimidoylphenyl)amino]-2-[5-ethoxy-2-flu...)
Affinity DataKi:  1.20E+3nMAssay Description:The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/5/2007
Entry Details Article
PubMed
TargetSerine protease 1(Bovine)
F. Hoffmann-La Roche

LigandPNGBDBM13589(2-[(4-carbamimidoylphenyl)amino]-2-[5-ethoxy-2-flu...)
Affinity DataKi:  3.10E+3nMAssay Description:The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/5/2007
Entry Details Article
PubMed
TargetProthrombin(Human)
F. Hoffmann-La Roche

LigandPNGBDBM13589(2-[(4-carbamimidoylphenyl)amino]-2-[5-ethoxy-2-flu...)
Affinity DataKi:  7.10E+3nM ΔG°:  -6.95kcal/molepH: 7.8 T: 2°CAssay Description:The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/5/2007
Entry Details Article
PubMed