BDBM135112 US8846657, 3.2

SMILES C[C@H]1CC[C@H](Cn2c(nc3cc(nc(-c4cncc(Cl)c4)c23)-c2noc(=O)[nH]2)N2CCO[C@@H]3CCC[C@@H]23)CC1

InChI Key InChIKey=FDBWTMMKIZGUEZ-UHFFFAOYSA-N

Data  7 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 135112   

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM135112(US8846657, 3.2)
Affinity DataIC50: 1nMAssay Description:Methods: An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 wi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/9/2015
Entry Details
Go to US Patent

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM135112(US8846657, 3.2)
Affinity DataIC50: 1nMAssay Description:Methods: An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 wi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/15/2015
Entry Details
Go to US Patent

TargetCytochrome P450 3A4(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM135112(US8846657, 3.2)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM135112(US8846657, 3.2)
Affinity DataIC50: 3.10E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM135112(US8846657, 3.2)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
TargetCytochrome P450 2C8(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM135112(US8846657, 3.2)
Affinity DataIC50: 800nMAssay Description:Inhibition of CYP2C8 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM135112(US8846657, 3.2)
Affinity DataEC50: >3.00E+4nMAssay Description:Activation of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
LigandPNGBDBM135112(US8846657, 3.2)
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed