BDBM13268 BMS-354825 2-Heteroarylamino-thiazole Analog 12m::CHEMBL364623::N-(2-Chloro-6-methylphenyl)-2-[(2,6-dimethyl-4-pyrimidinyl)-amino]-1,3-thiazole-5-carboxamide::N-(2-chloro-6-methylphenyl)-2-[(2,6-dimethylpyrimidin-4-yl)amino]-1,3-thiazole-5-carboxamide

SMILES Cc1cc(Nc2ncc(s2)C(=O)Nc2c(C)cccc2Cl)nc(C)n1

InChI Key InChIKey=WFRLFWGASBLYTC-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 13268   

TargetTyrosine-protein kinase Lck(Human)
Bristol-Myers Squibb

LigandPNGBDBM13268(CHEMBL364623 | N-(2-Chloro-6-methylphenyl)-2-[(2,6...)
Affinity DataIC50: 1nMAssay Description:IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-33P] lab...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/22/2007
Entry Details Article
PubMed
TargetTyrosine-protein kinase Fgr(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM13268(CHEMBL364623 | N-(2-Chloro-6-methylphenyl)-2-[(2,6...)
Affinity DataIC50: 1nMAssay Description:Inhibitory activity against Fgr kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM13268(CHEMBL364623 | N-(2-Chloro-6-methylphenyl)-2-[(2,6...)
Affinity DataIC50: 1nMAssay Description:Inhibitory activity against Src tyrosine kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM13268(CHEMBL364623 | N-(2-Chloro-6-methylphenyl)-2-[(2,6...)
Affinity DataIC50: 1.00E+4nMAssay Description:inhibitory activity against Vascular endothelial growth factor receptor 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM13268(CHEMBL364623 | N-(2-Chloro-6-methylphenyl)-2-[(2,6...)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibitory activity against Cyclin-dependent kinase 4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM13268(CHEMBL364623 | N-(2-Chloro-6-methylphenyl)-2-[(2,6...)
Affinity DataIC50: 5.20E+3nMAssay Description:Inhibitory activity against HER2 kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase Fyn(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM13268(CHEMBL364623 | N-(2-Chloro-6-methylphenyl)-2-[(2,6...)
Affinity DataIC50: 1nMAssay Description:inhibitory activity against Fyn protein kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase HCK(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM13268(CHEMBL364623 | N-(2-Chloro-6-methylphenyl)-2-[(2,6...)
Affinity DataIC50: 2nMAssay Description:inhibitory activity against Hck kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM13268(CHEMBL364623 | N-(2-Chloro-6-methylphenyl)-2-[(2,6...)
Affinity DataIC50: 6nMAssay Description:inhibitory activity against Janus kinase 3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM13268(CHEMBL364623 | N-(2-Chloro-6-methylphenyl)-2-[(2,6...)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibitory activity against Cyclin-dependent kinase 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed