BDBM12547 6-chloro-N-[(3S)-1-[(2S)-1-(morpholin-4-yl)-1-oxopropan-2-yl]-2-oxopyrrolidin-3-yl]-1-benzothiophene-2-sulfonamide::Arylsulfonamide 1a::N-[(3S)-2-oxopyrrolidin-3-yl]sulfonamide, 1e

SMILES C[C@H](N1CC[C@H](NS(=O)(=O)c2cc3ccc(Cl)cc3s2)C1=O)C(=O)N1CCOCC1

InChI Key InChIKey=PHLKBODTBJLXRD-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 12547   

TargetCoagulation factor X(Human)
Glaxosmithkline

LigandPNGBDBM12547(N-[(3S)-2-oxopyrrolidin-3-yl]sulfonamide, 1e | 6-c...)
Affinity DataKi:  15nM ΔG°:  -10.7kcal/molepH: 7.8 T: 2°CAssay Description:The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrate. The hydrolysis rates of chromogenic substrate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2006
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Glaxosmithkline

LigandPNGBDBM12547(N-[(3S)-2-oxopyrrolidin-3-yl]sulfonamide, 1e | 6-c...)
Affinity DataKi:  15nM ΔG°:  -10.6kcal/molepH: 7.4 T: 2°CAssay Description:The ability of test compounds to inhibit human fXa in vitro was determined in a fluorescence assay using rhodamime 110, bis-(Boc-L-glycylglycyl-L-arg...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2007
Entry Details Article
PubMed