BDBM12072 (R)-[1-(4-Methoxybiphenyl-4-sulfonylamino)-2-methylpropyl]phosphonic Acid::CHEMBL202932::[(1R)-1-{[4-(4-methoxyphenyl)benzene]sulfonamido}-2-methylpropyl]phosphonic acid::alpha-arylsulfonylamino phosphonate 1R

SMILES COc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)N[C@@H](C(C)C)P(O)(O)=O

InChI Key InChIKey=BZVYQWLRCHLAGK-UHFFFAOYSA-N

Data  3 KI  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 12072   

TargetMatrix metalloproteinase-14(Human)
Università

Curated by ChEMBL
LigandPNGBDBM12072(CHEMBL202932 | (R)-[1-(4-Methoxybiphenyl-4-sulfony...)
Affinity DataIC50: 79nMAssay Description:Inhibition of MMP14More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Università

Curated by ChEMBL
LigandPNGBDBM12072(CHEMBL202932 | (R)-[1-(4-Methoxybiphenyl-4-sulfony...)
Affinity DataIC50: 8nMAssay Description:Inhibition of human recombinant MMP9 expressed in mouse myeloma cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeutrophil collagenase(Human)
Università

Curated by ChEMBL
LigandPNGBDBM12072(CHEMBL202932 | (R)-[1-(4-Methoxybiphenyl-4-sulfony...)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of MMP8More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Università

Curated by ChEMBL
LigandPNGBDBM12072(CHEMBL202932 | (R)-[1-(4-Methoxybiphenyl-4-sulfony...)
Affinity DataIC50: 2.60nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Università

Curated by ChEMBL
LigandPNGBDBM12072(CHEMBL202932 | (R)-[1-(4-Methoxybiphenyl-4-sulfony...)
Affinity DataIC50: 150nMAssay Description:Inhibition of MMP1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMatrilysin(Human)
Università

Curated by ChEMBL
LigandPNGBDBM12072(CHEMBL202932 | (R)-[1-(4-Methoxybiphenyl-4-sulfony...)
Affinity DataIC50: 460nMAssay Description:Inhibition of MMP7More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Università

Curated by ChEMBL
LigandPNGBDBM12072(CHEMBL202932 | (R)-[1-(4-Methoxybiphenyl-4-sulfony...)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of human recombinant MMP2 expressed in mouse myeloma cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Università

Curated by ChEMBL
LigandPNGBDBM12072(CHEMBL202932 | (R)-[1-(4-Methoxybiphenyl-4-sulfony...)
Affinity DataIC50: 52nMAssay Description:Inhibition of MMP3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeutrophil collagenase(Human)
Università

Curated by ChEMBL
LigandPNGBDBM12072(CHEMBL202932 | (R)-[1-(4-Methoxybiphenyl-4-sulfony...)
Affinity DataKi:  0.600nM ΔG°:  -12.6kcal/molepH: 7.5 T: 2°CAssay Description:Inhibition of the matrix metalloproteinases MMP-2, MMP-3, and MMP-8 has been determined by continuously monitoring the hydrolysis of the fluorescent ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2006
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Università

Curated by ChEMBL
LigandPNGBDBM12072(CHEMBL202932 | (R)-[1-(4-Methoxybiphenyl-4-sulfony...)
Affinity DataKi:  5nM ΔG°:  -11.3kcal/molepH: 7.5 T: 2°CAssay Description:Inhibition of the matrix metalloproteinases MMP-2, MMP-3, and MMP-8 has been determined by continuously monitoring the hydrolysis of the fluorescent ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2006
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Università

Curated by ChEMBL
LigandPNGBDBM12072(CHEMBL202932 | (R)-[1-(4-Methoxybiphenyl-4-sulfony...)
Affinity DataKi:  40nM ΔG°:  -10.1kcal/molepH: 7.5 T: 2°CAssay Description:Inhibition of the matrix metalloproteinases MMP-2, MMP-3, and MMP-8 has been determined by continuously monitoring the hydrolysis of the fluorescent ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2006
Entry Details Article
PubMed