BDBM11877 N-Hydroxy-4-{[4-(phenoxyphenyl]sulfonyl}-1- (2-propynyl)4-piperidinecarboxamide, Monohydrochloride::N-hydroxy-4-[(4-phenoxybenzene)sulfonyl]-1-(prop-2-yn-1-yl)piperidine-4-carboxamide hydrochloride::alpha-sulfone 27g

SMILES ONC(=O)C1(CCN(CC#C)CC1)S(=O)(=O)c1ccc(Oc2ccccc2)cc1

InChI Key InChIKey=QYCUMAKSYBUWER-UHFFFAOYSA-N

Data  6 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 11877   

Target72 kDa type IV collagenase(Human)
Pfizer

LigandPNGBDBM11877(N-Hydroxy-4-{[4-(phenoxyphenyl]sulfonyl}-1- (2-pro...)
Affinity DataKi:  0.130nMAssay Description:Inhibitors were assayed against purified hMMP-1, hMMP-2, hMMP-3, hMMP-8, hMMP-9, and hMMP-13 using an enzyme assay based on cleavage of the quenched ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2006
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

LigandPNGBDBM11877(N-Hydroxy-4-{[4-(phenoxyphenyl]sulfonyl}-1- (2-pro...)
Affinity DataKi:  0.220nMAssay Description:Inhibitors were assayed against purified hMMP-1, hMMP-2, hMMP-3, hMMP-8, hMMP-9, and hMMP-13 using an enzyme assay based on cleavage of the quenched ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2006
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Pfizer

LigandPNGBDBM11877(N-Hydroxy-4-{[4-(phenoxyphenyl]sulfonyl}-1- (2-pro...)
Affinity DataKi:  0.400nMAssay Description:Inhibitors were assayed against purified hMMP-1, hMMP-2, hMMP-3, hMMP-8, hMMP-9, and hMMP-13 using an enzyme assay based on cleavage of the quenched ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2006
Entry Details Article
PubMed
TargetNeutrophil collagenase(Human)
Pfizer

LigandPNGBDBM11877(N-Hydroxy-4-{[4-(phenoxyphenyl]sulfonyl}-1- (2-pro...)
Affinity DataKi:  0.850nMAssay Description:Inhibitors were assayed against purified hMMP-1, hMMP-2, hMMP-3, hMMP-8, hMMP-9, and hMMP-13 using an enzyme assay based on cleavage of the quenched ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2006
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Pfizer

LigandPNGBDBM11877(N-Hydroxy-4-{[4-(phenoxyphenyl]sulfonyl}-1- (2-pro...)
Affinity DataKi:  12.6nMAssay Description:Inhibitors were assayed against purified hMMP-1, hMMP-2, hMMP-3, hMMP-8, hMMP-9, and hMMP-13 using an enzyme assay based on cleavage of the quenched ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2006
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Pfizer

LigandPNGBDBM11877(N-Hydroxy-4-{[4-(phenoxyphenyl]sulfonyl}-1- (2-pro...)
Affinity DataKi:  274nM ΔG°:  -8.95kcal/molepH: 7.5 T: 2°CAssay Description:Inhibitors were assayed against purified hMMP-1, hMMP-2, hMMP-3, hMMP-8, hMMP-9, and hMMP-13 using an enzyme assay based on cleavage of the quenched ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2006
Entry Details Article
PubMed