BDBM11875 1-Cyclopropyl-N-hydroxy-4-{[4-(phenoxyphenyl]-sulfonyl}piperidine-4-carboxamide Hydrochloride::1-cyclopropyl-N-hydroxy-4-[(4-phenoxybenzene)sulfonyl]piperidine-4-carboxamide hydrochloride::alpha-sulfone 27e

SMILES ONC(=O)C1(CCN(CC1)C1CC1)S(=O)(=O)c1ccc(Oc2ccccc2)cc1

InChI Key InChIKey=YLRBOIVJMWEGGX-UHFFFAOYSA-N

Data  6 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 11875   

Target72 kDa type IV collagenase(Human)
Pfizer

LigandPNGBDBM11875(1-cyclopropyl-N-hydroxy-4-[(4-phenoxybenzene)sulfo...)
Affinity DataKi:  0.200nMAssay Description:Inhibitors were assayed against purified hMMP-1, hMMP-2, hMMP-3, hMMP-8, hMMP-9, and hMMP-13 using an enzyme assay based on cleavage of the quenched ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2006
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Pfizer

LigandPNGBDBM11875(1-cyclopropyl-N-hydroxy-4-[(4-phenoxybenzene)sulfo...)
Affinity DataKi:  0.300nMAssay Description:Inhibitors were assayed against purified hMMP-1, hMMP-2, hMMP-3, hMMP-8, hMMP-9, and hMMP-13 using an enzyme assay based on cleavage of the quenched ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2006
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

LigandPNGBDBM11875(1-cyclopropyl-N-hydroxy-4-[(4-phenoxybenzene)sulfo...)
Affinity DataKi:  0.300nMAssay Description:Inhibitors were assayed against purified hMMP-1, hMMP-2, hMMP-3, hMMP-8, hMMP-9, and hMMP-13 using an enzyme assay based on cleavage of the quenched ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2006
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Pfizer

LigandPNGBDBM11875(1-cyclopropyl-N-hydroxy-4-[(4-phenoxybenzene)sulfo...)
Affinity DataKi:  0.600nMAssay Description:Inhibitors were assayed against purified hMMP-1, hMMP-2, hMMP-3, hMMP-8, hMMP-9, and hMMP-13 using an enzyme assay based on cleavage of the quenched ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2006
Entry Details Article
PubMed
TargetNeutrophil collagenase(Human)
Pfizer

LigandPNGBDBM11875(1-cyclopropyl-N-hydroxy-4-[(4-phenoxybenzene)sulfo...)
Affinity DataKi:  12.1nMAssay Description:Inhibitors were assayed against purified hMMP-1, hMMP-2, hMMP-3, hMMP-8, hMMP-9, and hMMP-13 using an enzyme assay based on cleavage of the quenched ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2006
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Pfizer

LigandPNGBDBM11875(1-cyclopropyl-N-hydroxy-4-[(4-phenoxybenzene)sulfo...)
Affinity DataKi:  400nM ΔG°:  -8.72kcal/molepH: 7.5 T: 2°CAssay Description:Inhibitors were assayed against purified hMMP-1, hMMP-2, hMMP-3, hMMP-8, hMMP-9, and hMMP-13 using an enzyme assay based on cleavage of the quenched ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2006
Entry Details Article
PubMed