BDBM11848 3-phenyl-N-{1-[(5-sulfanyl-1,3,4-thiadiazol-2-yl)carbamoyl]ethyl}-2-{[3-(trifluoromethyl)benzene]sulfonamido}propanamide::5-mercapto-1,3,4-thiadiazole 12n

SMILES CC(NC(=O)C(Cc1ccccc1)NS(=O)(=O)c1cccc(c1)C(F)(F)F)C(=O)Nc1nnc(S)s1

InChI Key InChIKey=OMBKWZNZMXWHMG-UHFFFAOYSA-N

Data  5 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 11848   

TargetNeutrophil collagenase(Human)
Universita Degli Studi Di Firenze

LigandPNGBDBM11848(3-phenyl-N-{1-[(5-sulfanyl-1,3,4-thiadiazol-2-yl)c...)
Affinity DataKi:  3.00E+3nMAssay Description:Initial rates for the hydrolysis of the thioester substrate were used for assessing the catalytic activity and inhibition of the MMPs by the spectrop...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2006
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Universita Degli Studi Di Firenze

LigandPNGBDBM11848(3-phenyl-N-{1-[(5-sulfanyl-1,3,4-thiadiazol-2-yl)c...)
Affinity DataKi:  5.00E+3nMAssay Description:Initial rates for the hydrolysis of the thioester substrate were used for assessing the catalytic activity and inhibition of the MMPs by the spectrop...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2006
Entry Details Article
PubMed
TargetCollagenase ColG(Hathewaya histolytica)
Universita Degli Studi Di Firenze

LigandPNGBDBM11848(3-phenyl-N-{1-[(5-sulfanyl-1,3,4-thiadiazol-2-yl)c...)
Affinity DataKi:  9.00E+3nMAssay Description:Initial rates for the hydrolysis of the thioester substrate were used for assessing the catalytic activity and inhibition of the MMPs by the spectrop...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2006
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Universita Degli Studi Di Firenze

LigandPNGBDBM11848(3-phenyl-N-{1-[(5-sulfanyl-1,3,4-thiadiazol-2-yl)c...)
Affinity DataKi:  1.10E+4nMAssay Description:Initial rates for the hydrolysis of the thioester substrate were used for assessing the catalytic activity and inhibition of the MMPs by the spectrop...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2006
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Universita Degli Studi Di Firenze

LigandPNGBDBM11848(3-phenyl-N-{1-[(5-sulfanyl-1,3,4-thiadiazol-2-yl)c...)
Affinity DataKi:  1.30E+4nM ΔG°:  -6.59kcal/molepH: 6.0 T: 2°CAssay Description:Initial rates for the hydrolysis of the thioester substrate were used for assessing the catalytic activity and inhibition of the MMPs by the spectrop...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2006
Entry Details Article
PubMed