BDBM11634 2,3,4,5,6-pentafluoro-N-(3-methyl-5-sulfamoyl-2,3-dihydro-1,3,4-thiadiazol-2-ylidene)benzamide::Sulfonamide 1::heterocyclic sulfonamide compound 38

SMILES Cn1nc(sc1=NC(=O)c1c(F)c(F)c(F)c(F)c1F)S(N)(=O)=O

InChI Key InChIKey=XEEATOCFEUTHHG-UHFFFAOYSA-N

Data  6 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 11634   

TargetCarbonic anhydrase 2(Human)
Istituto Di Biostrutture E Bioimmagini-Cnr

LigandPNGBDBM11634(heterocyclic sulfonamide compound 38 | 2,3,4,5,6-p...)
Affinity DataKi:  1.5nM ΔG°:  -11.9kcal/molepH: 7.5 T: 2°CAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2006
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Istituto Di Biostrutture E Bioimmagini-Cnr

LigandPNGBDBM11634(heterocyclic sulfonamide compound 38 | 2,3,4,5,6-p...)
Affinity DataKi:  1.5nMAssay Description:Initial rates of 4-nitrophenyl acetate hydrolysis catalyzed by different CA isozymes were monitored spectrophotometrically at 400 nm. A molar absorpt...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2007
Entry Details Article
PubMed
TargetCarbonic anhydrase 4(Bovine)
Universita Degli Studi Di Firenze

LigandPNGBDBM11634(heterocyclic sulfonamide compound 38 | 2,3,4,5,6-p...)
Affinity DataKi:  8nMAssay Description:Initial rates of 4-nitrophenyl acetate hydrolysis catalyzed by different CA isozymes were monitored spectrophotometrically at 400 nm. A molar absorpt...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2007
Entry Details Article
PubMed
TargetCarbonic anhydrase 5A, mitochondrial(Mouse)
Universita Degli Studi Di Firenze

LigandPNGBDBM11634(heterocyclic sulfonamide compound 38 | 2,3,4,5,6-p...)
Affinity DataKi:  14nMAssay Description:Initial rates of 4-nitrophenyl acetate hydrolysis catalyzed by different CA isozymes were monitored spectrophotometrically at 400 nm. A molar absorpt...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2007
Entry Details Article
PubMed
TargetCarbonic anhydrase 9(Human)
Istituto Di Biostrutture E Bioimmagini-Cnr

LigandPNGBDBM11634(heterocyclic sulfonamide compound 38 | 2,3,4,5,6-p...)
Affinity DataKi:  29nM ΔG°:  -10.2kcal/molepH: 7.5 T: 2°CAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2006
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
Universita Degli Studi Di Firenze

LigandPNGBDBM11634(heterocyclic sulfonamide compound 38 | 2,3,4,5,6-p...)
Affinity DataKi:  270nMAssay Description:Initial rates of 4-nitrophenyl acetate hydrolysis catalyzed by different CA isozymes were monitored spectrophotometrically at 400 nm. A molar absorpt...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2007
Entry Details Article
PubMed