BDBM116232 US10683287, Example 7::US8637508, 7

SMILES NC(=S)c1ccc(nc1)C(=O)Nc1cccc(n1)C1(CF)COCC([NH3+])=N1

InChI Key InChIKey=RWYPCDYBONWERI-UHFFFAOYSA-O

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 116232   

TargetBeta-secretase 1(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 116232BDBM116232(US8637508, 7 | US10683287, Example 7)
Affinity DataIC50: 2.10E+3nMpH: 4.5 T: 2°CAssay Description:Recombinant BACE-1 (extracellular domain, expressed in baculovirus and purified using standard methods) at 0.1 to 10 nM concentrations is incubated w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2014
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 116232BDBM116232(US8637508, 7 | US10683287, Example 7)
Affinity DataIC50: 2.10E+3nMAssay Description:Recombinant BACE-1 (extracellular domain, expressed in baculovirus and purified using standard methods) at 0.1 to 10 nM concentrations is incubated w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/15/2021
Entry Details
US Patent

TargetBeta-secretase 2(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 116232BDBM116232(US8637508, 7 | US10683287, Example 7)
Affinity DataIC50: 8.70E+3nMpH: 4.5 T: 2°CAssay Description:Recombinant BACE-2 (extracellular domain, expressed in baculovirus and purified using standard methods) at 0.1 to 10 nM concentrations is incubated w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2014
Entry Details
US Patent

TargetBeta-secretase 2(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 116232BDBM116232(US8637508, 7 | US10683287, Example 7)
Affinity DataIC50: 8.70E+3nMAssay Description:Recombinant BACE-2 (extracellular domain, expressed in baculovirus and purified using standard methods) at 0.1 to 10 nM concentrations is incubated w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/15/2021
Entry Details
US Patent