BDBM11463 CHEMBL22310::N-{4-[(1S)-1-amino-2-[(3S)-3-fluoropyrrolidin-1-yl]-2-oxoethyl]cyclohexyl}-2,4-difluorobenzene-1-sulfonamide::difluorobenzenesulfonamide 1

SMILES [H][C@@]1(CC[C@@H](CC1)NS(=O)(=O)c1ccc(F)cc1F)[C@H](N)C(=O)N1CC[C@H](F)C1

InChI Key InChIKey=QTZTUCOZZMQUFY-UHFFFAOYSA-N

Data  2 KI  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 11463   

TargetDipeptidyl peptidase 4(Human)
Merck Research Laboratories

LigandPNGBDBM11463(N-{4-[(1S)-1-amino-2-[(3S)-3-fluoropyrrolidin-1-yl...)
Affinity DataIC50: 48nMpH: 7.5 T: 2°CAssay Description:The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2006
Entry Details Article
PubMed
TargetDipeptidyl peptidase 8(Human)
Merck Research Laboratories

LigandPNGBDBM11463(N-{4-[(1S)-1-amino-2-[(3S)-3-fluoropyrrolidin-1-yl...)
Affinity DataIC50: 993nMAssay Description:The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2006
Entry Details Article
PubMed
TargetDipeptidyl peptidase 9(Human)
Merck Research Laboratories

LigandPNGBDBM11463(N-{4-[(1S)-1-amino-2-[(3S)-3-fluoropyrrolidin-1-yl...)
Affinity DataIC50: 2.72E+3nMAssay Description:The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2006
Entry Details Article
PubMed
TargetDipeptidyl peptidase 4(Human)
Merck Research Laboratories

LigandPNGBDBM11463(N-{4-[(1S)-1-amino-2-[(3S)-3-fluoropyrrolidin-1-yl...)
Affinity DataIC50: 48nMAssay Description:Inhibitory activity against human Dipeptidylpeptidase IVMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDipeptidyl peptidase 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM11463(N-{4-[(1S)-1-amino-2-[(3S)-3-fluoropyrrolidin-1-yl...)
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibitory activity against human quiescent cell proline dipeptidase (QPP) enzymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDipeptidyl peptidase 4(Human)
Merck Research Laboratories

LigandPNGBDBM11463(N-{4-[(1S)-1-amino-2-[(3S)-3-fluoropyrrolidin-1-yl...)
Affinity DataIC50: 48nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetDipeptidyl peptidase 8(Human)
Merck Research Laboratories

LigandPNGBDBM11463(N-{4-[(1S)-1-amino-2-[(3S)-3-fluoropyrrolidin-1-yl...)
Affinity DataIC50: 993nMAssay Description:Inhibition of DPP8More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetDipeptidyl peptidase 9(Human)
Merck Research Laboratories

LigandPNGBDBM11463(N-{4-[(1S)-1-amino-2-[(3S)-3-fluoropyrrolidin-1-yl...)
Affinity DataIC50: 2.72E+3nMAssay Description:Inhibition of DPP9More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM11463(N-{4-[(1S)-1-amino-2-[(3S)-3-fluoropyrrolidin-1-yl...)
Affinity DataKi:  4.90E+4nMAssay Description:Binding affinity towards human ERG potassium ion channel was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM11463(N-{4-[(1S)-1-amino-2-[(3S)-3-fluoropyrrolidin-1-yl...)
Affinity DataKi:  4.90E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed