BDBM11242 5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide::med.21724, Compound 76::niclosamide

SMILES c1cc(c(cc1[N+](=O)[O-])Cl)NC(=O)c2cc(ccc2O)Cl

InChI Key InChIKey=RJMUSRYZPJIFPJ-UHFFFAOYSA-N

Data  31 IC50

PDB links: 2 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 31 hits for monomerid = 11242   

TargetAnoctamin-1(Human)
Peking University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 11242BDBM11242(5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenza...)
Affinity DataIC50: 28nMAssay Description:Inhibition of YFP tagged ANO1 (unknown origin) expressed in FRT cells incubated for 24 hrs by fluorescence plate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetSignal transducer and activator of transcription 3(Human)
The First Affiliated Hospital of Wenzhou Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 11242BDBM11242(5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenza...)
Affinity DataIC50: 210nMAssay Description:Inhibition of STAT3 phosphorylation in human MDA-MB-231 cells by sandwich ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSignal transducer and activator of transcription 3(Human)
The First Affiliated Hospital of Wenzhou Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 11242BDBM11242(5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenza...)
Affinity DataIC50: 250nMAssay Description:Inhibition of STAT3 in human HeLa cells after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetReplicase polyprotein 1ab(2019-nCoV)
Institut Pasteur Korea

LigandChemical structure of BindingDB Monomer ID 11242BDBM11242(5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenza...)
Affinity DataIC50: 280nMAssay Description:Ten-point DRCs were generated for each drug. Vero cells were seeded at 1.2 × 104 cells per well in DMEM, supplemented with 2% FBS and 1× ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2020
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Institut Pasteur Korea

LigandChemical structure of BindingDB Monomer ID 11242BDBM11242(5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenza...)
Affinity DataIC50: 280nMAssay Description:Inhibition of SARS-CoV-2 main proteaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetSignal transducer and activator of transcription 3(Human)
The First Affiliated Hospital of Wenzhou Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 11242BDBM11242(5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenza...)
Affinity DataIC50: 1.93E+3nMAssay Description:Inhibition of human recombinant STAT3 assessed as reduction in DNA binding activity with HepG2 nuclear extract incubated for 1 hr by ELISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase JAK2(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 11242BDBM11242(5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenza...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of JAK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 11242BDBM11242(5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenza...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Src kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 11242BDBM11242(5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenza...)
Affinity DataIC50: 1.05E+4nMAssay Description:Inhibition of EGFR after 60 mins by radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 11242BDBM11242(5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenza...)
Affinity DataIC50: 1.05E+4nMAssay Description:Inhibition of Src kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 11242BDBM11242(5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenza...)
Affinity DataIC50: 1.31E+4nMAssay Description:Inhibition of FGFR-1 after 60 mins by radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 11242BDBM11242(5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenza...)
Affinity DataIC50: 2.31E+4nMAssay Description:Inhibition of VEGFR2 after 60 mins by radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lyn(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 11242BDBM11242(5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenza...)
Affinity DataIC50: 2.38E+4nMAssay Description:Inhibition of LYN after 60 mins by radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 11242BDBM11242(5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenza...)
Affinity DataIC50: 2.78E+4nMAssay Description:Inhibition of KIT after 60 mins by radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(SARS-CoV)
National Human Genome Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 11242BDBM11242(5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenza...)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of SARS Co-V 3CL proteaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(SARS-CoV)
National Human Genome Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 11242BDBM11242(5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenza...)
Affinity DataIC50: 5.00E+4nMAssay Description:This is a review article.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(SARS-CoV)
National Human Genome Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 11242BDBM11242(5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenza...)
Affinity DataIC50: 5.00E+4nMAssay Description:This is a review article.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(SARS-CoV)
National Human Genome Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 11242BDBM11242(5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenza...)
Affinity DataIC50: 5.00E+4nMpH: 7.0 T: 2°CAssay Description:The effects of compound on enzyme activity were measured by using a fluorogenic peptide cleavage assay. Enhanced fluorescence caused by cleavage of t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2006
Entry Details Article
PubMed
TargetAurora kinase A(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 11242BDBM11242(5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenza...)
Affinity DataIC50: 5.41E+4nMAssay Description:Inhibition of Aurora-A after 60 mins by radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 11242BDBM11242(5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenza...)
Affinity DataIC50: 5.94E+4nMAssay Description:Inhibition of Akt1 after 60 mins by radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetAngiopoietin-1 receptor(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 11242BDBM11242(5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenza...)
Affinity DataIC50: 6.78E+4nMAssay Description:Inhibition of TIE2 after 60 mins by radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 11242BDBM11242(5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenza...)
Affinity DataIC50: 7.75E+4nMAssay Description:Inhibition of GSK3-beta after 60 mins by radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 11242BDBM11242(5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenza...)
Affinity DataIC50: 8.39E+4nMAssay Description:Inhibition of PDK1 after 60 mins by radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 8(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 11242BDBM11242(5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenza...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of JNK1 after 60 mins by radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 11242BDBM11242(5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenza...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of PDGFR-beta after 60 mins by radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 11242BDBM11242(5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenza...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of Abl1 after 60 mins by radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetProtein kinase C alpha type(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 11242BDBM11242(5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenza...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of PKC-alpha after 60 mins by radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 11242BDBM11242(5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenza...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of B-Raf after 60 mins by radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 11242BDBM11242(5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenza...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of Erk2 after 60 mins by radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 11242BDBM11242(5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenza...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of Flt3 after 60 mins by radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 11242BDBM11242(5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenza...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of JAK2 after 60 mins by radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed