BDBM106769 1‐benzyl‐2‐phenyl‐1,3‐benzodiazole (B10)

SMILES C(c1ccccc1)n1c(nc2ccccc12)-c1ccccc1

InChI Key InChIKey=LCFXRSKBJWQHON-UHFFFAOYSA-N

Data  4 IC50  3 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 106769   

TargetXanthine dehydrogenase/oxidase(Bovine)
Konkuk University

LigandPNGBDBM106769(1‐benzyl‐2‐phenyl‐1,3̴...)
Affinity DataIC50: 9.70E+3nMpH: 7.6 T: 2°CAssay Description:Bovine milk XO activity was assayed spectrophotometrically by measuring the uric acid formation at 293 nm using a UV-visible spectrophotometer at 25&...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2014
Entry Details Article
PubMed
TargetRetinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta(Human)
Max Planck Institute of Molecular Physiology

Curated by ChEMBL
LigandPNGBDBM106769(1‐benzyl‐2‐phenyl‐1,3̴...)
Affinity DataKd:  2.90E+3nMAssay Description:Binding affinity to PDE-delta (unknown origin) by time-resolved fluorescence anisotropic analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
TargetRetinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta(Human)
Max Planck Institute of Molecular Physiology

Curated by ChEMBL
LigandPNGBDBM106769(1‐benzyl‐2‐phenyl‐1,3̴...)
Affinity DataKd:  2.40E+3nMAssay Description:Binding affinity to PDE-delta (unknown origin) by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
TargetRetinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta(Human)
Max Planck Institute of Molecular Physiology

Curated by ChEMBL
LigandPNGBDBM106769(1‐benzyl‐2‐phenyl‐1,3̴...)
Affinity DataKd:  165nMAssay Description:Inhibition of atorvastatin PEG-fluorescein binding to PDEdelta (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2019
Entry Details Article
PubMed
TargetAldehyde dehydrogenase 1A1(Human)
Punjabi University

Curated by ChEMBL
LigandPNGBDBM106769(1‐benzyl‐2‐phenyl‐1,3̴...)
Affinity DataIC50: 8.67E+3nMAssay Description:Inhibition of human ALDH1A1 using propionaldehyde as substrate preincubated with enzyme for 15 mins followed by substrate addition in presence of NAD...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetAldehyde dehydrogenase, mitochondrial(Human)
Punjabi University

Curated by ChEMBL
LigandPNGBDBM106769(1‐benzyl‐2‐phenyl‐1,3̴...)
Affinity DataIC50: 9.56E+4nMAssay Description:Inhibition of human ALDH2 using acetaldehyde as substrate preincubated with enzyme for 15 mins followed by substrate addition in presence of NAD+ and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetAldehyde dehydrogenase, dimeric NADP-preferring(Human)
Punjabi University

Curated by ChEMBL
LigandPNGBDBM106769(1‐benzyl‐2‐phenyl‐1,3̴...)
Affinity DataIC50: 9.83E+4nMAssay Description:Inhibition of human ALDH3A1 using 4-nitrobenzaldehyde as substrate preincubated with enzyme for 15 mins followed by substrate addition in presence of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed