BDBM10666 (3S)-5-(benzylsulfanyl)-3-[(2S)-2-[1-(3-methoxyphenyl)acetamido]-3-methylbutanamido]-4-oxopentanoic acid::valine aspartyl ketone analog 8

SMILES COc1cccc(CC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)CSCc2ccccc2)c1

InChI Key InChIKey=RHPCNWBBSVNQEY-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 10666   

TargetCaspase-3(Human)
Merck Frosst Canada

LigandPNGBDBM10666((3S)-5-(benzylsulfanyl)-3-[(2S)-2-[1-(3-methoxyphe...)
Affinity DataIC50: 210nMpH: 7.0 T: 2°CAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors, and the accumulation of AMC was assessed with a Cytof...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2006
Entry Details Article
PubMed
TargetCaspase-1(Human)
Merck Frosst Canada

LigandPNGBDBM10666((3S)-5-(benzylsulfanyl)-3-[(2S)-2-[1-(3-methoxyphe...)
Affinity DataIC50: 1.40E+4nMAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors, and the accumulation of AMC was assessed with a Cytof...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2006
Entry Details Article
PubMed
TargetCaspase-7(Human)
Merck Frosst Canada

LigandPNGBDBM10666((3S)-5-(benzylsulfanyl)-3-[(2S)-2-[1-(3-methoxyphe...)
Affinity DataIC50: 3.10E+3nMAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors, and the accumulation of AMC was assessed with a Cytof...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2006
Entry Details Article
PubMed
TargetCaspase-8(Human)
Merck Frosst Canada

LigandPNGBDBM10666((3S)-5-(benzylsulfanyl)-3-[(2S)-2-[1-(3-methoxyphe...)
Affinity DataIC50: 1.40E+4nMAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors, and the accumulation of AMC was assessed with a Cytof...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2006
Entry Details Article
PubMed