BDBM103728 US10206907, Compound 18::US11000528, Cpd # 2::US8563545, 2

SMILES O=C(Nc1nc2cccc(-c3ccc(CN4CCOCC4)cc3)n2n1)C1CC1

InChI Key InChIKey=XDPDUHYHLILQIX-UHFFFAOYSA-N

Data  18 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 103728   

TargetTyrosine-protein kinase JAK1(Human)
Galapagos

Curated by ChEMBL
LigandPNGBDBM103728(US8563545, 2 | US10206907, Compound 18 | US1100052...)
Affinity DataIC50: 92nMAssay Description:Inhibition of human recombinant JAK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2016
Entry Details Article
PubMed
LigandPNGBDBM103728(US8563545, 2 | US10206907, Compound 18 | US1100052...)
Affinity DataIC50: 2.10E+3nMAssay Description:Recombinant human TYK2 catalytic domain (amino acids 871-1187; catalog number 08-147) was purchased from Carna biosciences. 5 ng of TYK2 was incubate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3 [781-1124](Human)
Galapagos

US Patent
LigandPNGBDBM103728(US8563545, 2 | US10206907, Compound 18 | US1100052...)
Affinity DataIC50: 2.84E+3nMAssay Description:Recombinant human JAK3 catalytic domain (amino acids 781-1124; catalog number PV3855) was purchased from Invitrogen. 0.025 mU of JAK3 was incubated w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2 [808-1132](Human)
Galapagos

US Patent
LigandPNGBDBM103728(US8563545, 2 | US10206907, Compound 18 | US1100052...)
Affinity DataIC50: 38.7nMAssay Description:Recombinant human JAK2 catalytic domain (amino acids 808-1132; catalog number PV4210) was purchased from Invitrogen. 0.025 mU of JAK2 was incubated w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1 [850-1154]()
Galapagos

US Patent
LigandPNGBDBM103728(US8563545, 2 | US10206907, Compound 18 | US1100052...)
Affinity DataIC50: 50.9nMAssay Description:Recombinant human JAK1 catalytic domain (amino acids 850-1154; catalog number 08-144) was purchased from Carna Biosciences. 10 ng of JAK1 was incubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2 [808-1132](Human)
Galapagos

US Patent
LigandPNGBDBM103728(US8563545, 2 | US10206907, Compound 18 | US1100052...)
Affinity DataIC50: 1.00E+3nMAssay Description:Recombinant human JAK2 catalytic domain (amino acids 808-1132; catalog number PV4210) was purchased from Invitrogen. 0.025 mU of JAK2 was incubated w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1 [850-1154](Human)
Galapagos

US Patent
LigandPNGBDBM103728(US8563545, 2 | US10206907, Compound 18 | US1100052...)
Affinity DataIC50: 100nMAssay Description:Recombinant human JAK1 catalytic domain (amino acids 850-1154; catalog number 08-144) was purchased from Carna Biosciences. 10 ng of JAK1 was incubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
Go to US Patent

LigandPNGBDBM103728(US8563545, 2 | US10206907, Compound 18 | US1100052...)
Affinity DataIC50: 1.00E+3nMAssay Description:Recombinant human TYK2 catalytic domain (amino acids 871-1187; catalog number 08-147) was purchased from Carna biosciences. 5 ng of TYK2 was incubate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3 [781-1124](Human)
Galapagos

US Patent
LigandPNGBDBM103728(US8563545, 2 | US10206907, Compound 18 | US1100052...)
Affinity DataIC50: 1.00E+3nMAssay Description:Recombinant human JAK3 catalytic domain (amino acids 781-1124; catalog number PV3855) was purchased from Invitrogen. 0.025 mU of JAK3 was incubated w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1(Human)
Galapagos

Curated by ChEMBL
LigandPNGBDBM103728(US8563545, 2 | US10206907, Compound 18 | US1100052...)
Affinity DataIC50: 50.9nMAssay Description:In vitro inhibition assay using various enzyme.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/14/2014
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1(Human)
Galapagos

Curated by ChEMBL
LigandPNGBDBM103728(US8563545, 2 | US10206907, Compound 18 | US1100052...)
Affinity DataIC50: 5.59E+3nMAssay Description:Inhibition of JAK1 in human whole blood assessed as inhibition of IL-6-induced pSTAT1More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Galapagos

Curated by ChEMBL
LigandPNGBDBM103728(US8563545, 2 | US10206907, Compound 18 | US1100052...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of JAK2 in human whole blood assessed as inhibition of GM-CSF-induced pSTAT5More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2016
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Galapagos

US Patent
LigandPNGBDBM103728(US8563545, 2 | US10206907, Compound 18 | US1100052...)
Affinity DataIC50: 2.10E+3nMAssay Description:In vitro inhibition assay using various enzyme.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/14/2014
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3(Human)
Galapagos

US Patent
LigandPNGBDBM103728(US8563545, 2 | US10206907, Compound 18 | US1100052...)
Affinity DataIC50: 2.84E+3nMAssay Description:In vitro inhibition assay using various enzyme.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/14/2014
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2(Human)
Galapagos

Curated by ChEMBL
LigandPNGBDBM103728(US8563545, 2 | US10206907, Compound 18 | US1100052...)
Affinity DataIC50: 185nMAssay Description:In vitro inhibition assay using various enzyme.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/14/2014
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2(Human)
Galapagos

Curated by ChEMBL
LigandPNGBDBM103728(US8563545, 2 | US10206907, Compound 18 | US1100052...)
Affinity DataIC50: 152nMAssay Description:In vitro inhibition assay using various enzyme.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/14/2014
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2(Human)
Galapagos

Curated by ChEMBL
LigandPNGBDBM103728(US8563545, 2 | US10206907, Compound 18 | US1100052...)
Affinity DataIC50: 38.7nMAssay Description:In vitro inhibition assay using various enzyme.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/14/2014
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1(Human)
Galapagos

Curated by ChEMBL
LigandPNGBDBM103728(US8563545, 2 | US10206907, Compound 18 | US1100052...)
Affinity DataIC50: 52.1nMAssay Description:In vitro inhibition assay using various enzyme.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/14/2014
Entry Details
Go to US Patent