BDBM10346 (S)-1-(2-Fluoropyridin-4-yl-methyl)-5-(2-phenoxymethyl-azetidine1-sulfonyl)-1H-indole-2,3-dione::1-[(2-fluoropyridin-4-yl)methyl]-5-{[(2S)-2-(phenoxymethyl)azetidine-1-]sulfonyl}-2,3-dihydro-1H-indole-2,3-dione::Azetidine Isatin Analogue 18h

SMILES Fc1cc(CN2C(=O)C(=O)c3cc(ccc23)S(=O)(=O)N2CC[C@H]2COc2ccccc2)ccn1

InChI Key InChIKey=RYWKNTKVPRMYNJ-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 10346   

TargetCaspase-3(Human)
Washington University

LigandPNGBDBM10346((S)-1-(2-Fluoropyridin-4-yl-methyl)-5-(2-phenoxyme...)
Affinity DataIC50: 29.2nMAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors. The amount of AMC released was determined by using a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2006
Entry Details Article
PubMed
TargetCaspase-7(Human)
Washington University

LigandPNGBDBM10346((S)-1-(2-Fluoropyridin-4-yl-methyl)-5-(2-phenoxyme...)
Affinity DataIC50: 135nMAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors. The amount of AMC released was determined by using a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2006
Entry Details Article
PubMed
TargetCaspase-1(Human)
Washington University

LigandPNGBDBM10346((S)-1-(2-Fluoropyridin-4-yl-methyl)-5-(2-phenoxyme...)
Affinity DataIC50: 5.00E+4nMAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors. The amount of AMC released was determined by using a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2006
Entry Details Article
PubMed
TargetCaspase-6(Human)
Washington University

LigandPNGBDBM10346((S)-1-(2-Fluoropyridin-4-yl-methyl)-5-(2-phenoxyme...)
Affinity DataIC50: 5.00E+3nMAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors. The amount of AMC released was determined by using a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2006
Entry Details Article
PubMed
TargetCaspase-8(Human)
Washington University

LigandPNGBDBM10346((S)-1-(2-Fluoropyridin-4-yl-methyl)-5-(2-phenoxyme...)
Affinity DataIC50: 5.00E+4nMAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors. The amount of AMC released was determined by using a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2006
Entry Details Article
PubMed
TargetCaspase-3(Human)
Washington University

LigandPNGBDBM10346((S)-1-(2-Fluoropyridin-4-yl-methyl)-5-(2-phenoxyme...)
Affinity DataIC50: 29.5nMAssay Description:Inhibition of caspase3More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed