BDBM10304 1-methyl-2,3-dihydro-1H-indole-2,3-dione::CHEMBL60569::Isatin analog 8::N‐methylindol‐2,3‐dione (Compound 2)

SMILES CN1c2ccccc2C(=O)C1=O

InChI Key InChIKey=VCYBVWFTGAZHGH-UHFFFAOYSA-N

Data  6 KI  3 IC50

PDB links: 3 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 10304   

TargetCaspase-3(Human)
Glaxosmithkline

LigandPNGBDBM10304(1-methyl-2,3-dihydro-1H-indole-2,3-dione | N‐...)
Affinity DataIC50: 5.00E+4nMpH: 7.5 T: 2°CAssay Description:The substrate peptides terminating in AMC/AFC are processed by caspases with or without inhibitors, and the accumulation of AMC/AFC was assessed with...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2006
Entry Details Article
PubMed
TargetSecreted chorismate mutase(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Birla Institute of Technology

LigandPNGBDBM10304(1-methyl-2,3-dihydro-1H-indole-2,3-dione | N‐...)
Affinity DataIC50: 1.96E+3nMT: 2°CAssay Description:The reaction was initiated by the addition of 150pmoles of enzyme to a mixture of inhibitor (40µM, 20 µM, 10 µM, 5 µM, 1 µM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2014
Entry Details Article
PubMed
TargetTransthyretin(Human)
Universitat De Barcelona

Curated by ChEMBL
LigandPNGBDBM10304(1-methyl-2,3-dihydro-1H-indole-2,3-dione | N‐...)
Affinity DataIC50: 6.30E+3nMAssay Description:Inhibition of TTR mediated fibrillogenesis assessed as acid-induced protein aggregation turbidity after 1.5 hrs by turbidimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetLiver carboxylesterase 1(Human)
St. Jude Research Hospital

LigandPNGBDBM10304(1-methyl-2,3-dihydro-1H-indole-2,3-dione | N‐...)
Affinity DataKi:  5.38E+3nMAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2008
Entry Details Article
PubMed
TargetCoagulation factor XII(Human)
St. Jude Research Hospital

LigandPNGBDBM10304(1-methyl-2,3-dihydro-1H-indole-2,3-dione | N‐...)
Affinity DataKi:  3.82E+4nM ΔG°:  -6.02kcal/molepH: 7.4 T: 2°CAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2008
Entry Details Article
PubMed
TargetLiver carboxylesterase 1(Rabbit)
St. Jude Research Hospital

LigandPNGBDBM10304(1-methyl-2,3-dihydro-1H-indole-2,3-dione | N‐...)
Affinity DataKi: >1.00E+5nMAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2008
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
St. Jude Research Hospital

LigandPNGBDBM10304(1-methyl-2,3-dihydro-1H-indole-2,3-dione | N‐...)
Affinity DataKi: >1.00E+5nMAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2008
Entry Details Article
PubMed
TargetCholinesterase(Human)
St. Jude Research Hospital

LigandPNGBDBM10304(1-methyl-2,3-dihydro-1H-indole-2,3-dione | N‐...)
Affinity DataKi: >1.00E+5nMAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2008
Entry Details Article
PubMed
TargetGenome polyprotein(Human rhinovirus B)
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM10304(1-methyl-2,3-dihydro-1H-indole-2,3-dione | N‐...)
Affinity DataKi: >1.00E+5nMAssay Description:Inhibition of human rhinovirus 3C proteaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed