BDBM10219 BI-9B11::Burnham Institute Compound 5::[2-(2,3-dihydro-1,4-benzodioxin-2-yl)-1,3-thiazol-4-yl](thiophen-2-ylsulfanyl)methanone

SMILES O=C(Sc1cccs1)c1csc(n1)C1COc2ccccc2O1

InChI Key InChIKey=CZEDIMGCHBDRMM-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 10219   

TargetCaspase-3(Human)
Burnham Institute

LigandPNGBDBM10219(BI-9B11 | [2-(2,3-dihydro-1,4-benzodioxin-2-yl)-1,...)
Affinity DataIC50: 5.50E+4nMpH: 7.5 T: 2°CAssay Description:Fluorescent assays were carried out in black 96-well plates. Caspase activity was monitored using a Labsystem Fluoroskan II spectrofluorometer with a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2006
Entry Details Article
PubMed
TargetCaspase-7(Human)
Burnham Institute

LigandPNGBDBM10219(BI-9B11 | [2-(2,3-dihydro-1,4-benzodioxin-2-yl)-1,...)
Affinity DataIC50: 2.00E+5nMAssay Description:Fluorescent assays were carried out in black 96-well plates. Caspase activity was monitored using a Labsystem Fluoroskan II spectrofluorometer with a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2006
Entry Details Article
PubMed
TargetCaspase-8(Human)
Burnham Institute

LigandPNGBDBM10219(BI-9B11 | [2-(2,3-dihydro-1,4-benzodioxin-2-yl)-1,...)
Affinity DataIC50: 6.20E+4nMAssay Description:Fluorescent assays were carried out in black 96-well plates. Caspase activity was monitored using a Labsystem Fluoroskan II spectrofluorometer with a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2006
Entry Details Article
PubMed