BDBM50236983 2-Hydroxy-cyclohepta-2,4,6-trienone::2-hydroxycyclohepta-2,4,6-trienone::CHEMBL121188::tropolone

SMILES C1=CC=C(C(=O)C=C1)O

InChI Key InChIKey=MDYOLVRUBBJPFM-UHFFFAOYSA-N

Data  1 KI  9 IC50

PDB links: 5 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50236983   

TargetPolyphenol oxidase 2(White button mushroom)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50236983(2-hydroxycyclohepta-2,4,6-trienone | tropolone | 2...)
Affinity DataIC50: 400nMAssay Description:Inhibition of mushroom tyrosinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetPolyphenol oxidase 2(White button mushroom)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50236983(2-hydroxycyclohepta-2,4,6-trienone | tropolone | 2...)
Affinity DataIC50: 400nMAssay Description:Inhibition of mushroom tyrosinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50236983(2-hydroxycyclohepta-2,4,6-trienone | tropolone | 2...)
Affinity DataIC50: 1.46E+5nMAssay Description:Inhibition of human recombinant MMP2 after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetPolyphenol oxidase 2(White button mushroom)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50236983(2-hydroxycyclohepta-2,4,6-trienone | tropolone | 2...)
Affinity DataIC50: 400nMAssay Description:Inhibition of mushroom tyrosinase after 10 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetPolyphenol oxidase 2(White button mushroom)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50236983(2-hydroxycyclohepta-2,4,6-trienone | tropolone | 2...)
Affinity DataIC50: 400nMAssay Description:Inhibition of mushroom tyrosinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetCarboxypeptidase A1(Bovine)
Osaka Organic Chemical Industry

Curated by ChEMBL
LigandPNGBDBM50236983(2-hydroxycyclohepta-2,4,6-trienone | tropolone | 2...)
Affinity DataIC50: 2.73E+3nMAssay Description:Inhibition of Bos taurus (bovine) pancrease carboxypeptidase A after 15 minMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetThermolysin(Bacillus thermoproteolyticus)
Osaka Organic Chemical Industry

Curated by ChEMBL
LigandPNGBDBM50236983(2-hydroxycyclohepta-2,4,6-trienone | tropolone | 2...)
Affinity DataIC50: 7.11E+4nMAssay Description:Inhibition of Bacillus thermoproteolyticus thermolysin after 15 minMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetCollagenase ColG(Hathewaya histolytica)
Osaka Organic Chemical Industry

Curated by ChEMBL
LigandPNGBDBM50236983(2-hydroxycyclohepta-2,4,6-trienone | tropolone | 2...)
Affinity DataIC50: 4.68E+4nMAssay Description:Inhibition of Clostridium histolyticum collagenase after 15 minMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetDopamine beta-hydroxylase(Human)
City University of New York

Curated by ChEMBL
LigandPNGBDBM50236983(2-hydroxycyclohepta-2,4,6-trienone | tropolone | 2...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of dopamine beta-oxygenase (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetPolyphenol oxidase 4(Agaricus bisporus)
Univ. Grenoble Alpes

Curated by ChEMBL
LigandPNGBDBM50236983(2-hydroxycyclohepta-2,4,6-trienone | tropolone | 2...)
Affinity DataKi:  8.00E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed