BDBM50338975 2-(3,4-dimethoxyphenyl)-5,6,7-trimethoxy-4H-chromen-4-one::3',4',5,6,7-pentamethoxy flavone::5,6,7,3',4' -pentamethoxyflavone::CHEMBL226507::Sinensetin (3)::sinensetin

SMILES COc1ccc(cc1OC)-c1cc(=O)c2c(OC)c(OC)c(OC)cc2o1

InChI Key InChIKey=LKMNXYDUQXAUCZ-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50338975   

TargetAurora kinase B(Human)
Konkuk University

LigandPNGBDBM50338975(2-(3,4-dimethoxyphenyl)-5,6,7-trimethoxy-4H-chrome...)
Affinity DataIC50: 5.31E+3nMAssay Description:The kinase assay was performed using the EMD Millipore KinaseProfiler service assay protocol. Aurora B kinase was supplied by EMD Millipore Corp. The...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2015
Entry Details Article
PubMed
LigandPNGBDBM50338975(2-(3,4-dimethoxyphenyl)-5,6,7-trimethoxy-4H-chrome...)
Affinity DataIC50: 8.30E+3nMAssay Description:Inhibition of BCRP expressed in MCF-7 MX cells using Hoechst 33342 stainingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
LigandPNGBDBM50338975(2-(3,4-dimethoxyphenyl)-5,6,7-trimethoxy-4H-chrome...)
Affinity DataIC50: 9.00E+3nMAssay Description:Inhibition of BCRP expressed in MDCK cells using Hoechst 33342 stainingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50338975(2-(3,4-dimethoxyphenyl)-5,6,7-trimethoxy-4H-chrome...)
Affinity DataIC50: 2.90E+4nMAssay Description:Inhibition of MDR1 expressed in MDCK cells using rhodamine 123 staining by flow cytometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50338975(2-(3,4-dimethoxyphenyl)-5,6,7-trimethoxy-4H-chrome...)
Affinity DataIC50: 3.20E+3nMAssay Description:TP_TRANSPORTER: drug resistance (vincristine) in AML-2/D100 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetDNA polymerase eta(Human)
Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandPNGBDBM50338975(2-(3,4-dimethoxyphenyl)-5,6,7-trimethoxy-4H-chrome...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of C-terminal 6xHis-tagged human DNA polymerase eta (1 to 511 residues) expressed in Escherichia coli BL21 DE3 using 5'-IRD700-GCAGGTCGACT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed