BDBM50325534 CHEMBL267495::nalfurafine

SMILES CN([C@@H]1CC[C@]2([C@H]3Cc4ccc(c5c4[C@]2([C@H]1O5)CCN3CC6CC6)O)O)C(=O)/C=C/c7ccoc7

InChI Key InChIKey=XGZZHZMWIXFATA-UHFFFAOYSA-N

Data  16 KI  12 EC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 28 hits for monomerid = 50325534   

TargetMitogen-activated protein kinase 1(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50325534(nalfurafine | CHEMBL267495)
Affinity DataEC50:  0.550nMAssay Description:Inhibition of ERK2 phosphorylation (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 11/12/13/14(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50325534(nalfurafine | CHEMBL267495)
Affinity DataEC50:  5.20nMAssay Description:Inhibition of p38 phosphorylation (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50325534(nalfurafine | CHEMBL267495)
Affinity DataEC50:  110nMAssay Description:Agonist activity at FLAG-tagged human kappa opioid receptor expressed in HEK293 cells assessed as increase in beta-arrestin mediated p38 phosphorylat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetKappa-type opioid receptor(Human)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50325534(nalfurafine | CHEMBL267495)
Affinity DataEC50:  1.40nMAssay Description:Agonist activity at FLAG-tagged human kappa opioid receptor expressed in HEK293 cells assessed as increase in ERK1/2 phosphorylation after 5 mins by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetKappa-type opioid receptor(Rat)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50325534(nalfurafine | CHEMBL267495)
Affinity DataEC50:  0.5nMAssay Description:Agonist activity at GFP-tagged rat kappa opioid receptor expressed in HEK293 cells assessed as increase in ERK1/2 phosphorylation after 5 mins by Wes...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetKappa-type opioid receptor(Rat)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50325534(nalfurafine | CHEMBL267495)
Affinity DataEC50:  5.20nMAssay Description:Agonist activity at GFP-tagged rat kappa opioid receptor expressed in HEK293 cells assessed as increase in beta-arrestin mediated p38 phosphorylation...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetKappa-type opioid receptor(Human)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50325534(nalfurafine | CHEMBL267495)
Affinity DataEC50:  0.0250nMAssay Description:Agonist activity at human kappa opioid receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase 3(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50325534(nalfurafine | CHEMBL267495)
Affinity DataEC50:  0.550nMAssay Description:Inhibition of ERK1 phosphorylation (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50325534(nalfurafine | CHEMBL267495)
Affinity DataEC50:  0.0340nMAssay Description:Agonist activity at kappa opioid receptor in human HEK293 cells after 30 mins by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetKappa-type opioid receptor(Human)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50325534(nalfurafine | CHEMBL267495)
Affinity DataEC50:  0.0500nMAssay Description:Agonist activity at human kappa opioid receptor expressed in CHO cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetDelta-type opioid receptor(Human)
Kitasato University

Curated by ChEMBL
LigandPNGBDBM50325534(nalfurafine | CHEMBL267495)
Affinity DataEC50:  74nMAssay Description:Agonist activity at human delta opioid receptor expressed in CHO cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2016
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Kitasato University

Curated by ChEMBL
LigandPNGBDBM50325534(nalfurafine | CHEMBL267495)
Affinity DataEC50:  0.720nMAssay Description:Agonist activity at human mu opioid receptor expressed in CHO cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2016
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50325534(nalfurafine | CHEMBL267495)
Affinity DataKi:  0.0190nMAssay Description:Displacement of [3H]DPDPE from human KOR expressed in HEK293 cell membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetKappa-type opioid receptor(Guinea pig)
Mercachem

Curated by ChEMBL
LigandPNGBDBM50325534(nalfurafine | CHEMBL267495)
Affinity DataKi:  0.170nMAssay Description:Displacement of [3H]-U-69593 from kappa opioid receptor in guinea pig brain membrane after 120 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetKappa-type opioid receptor(Guinea pig)
Mercachem

Curated by ChEMBL
LigandPNGBDBM50325534(nalfurafine | CHEMBL267495)
Affinity DataKi:  0.180nMAssay Description:Displacement of [3H]U-69593 from kappa opioid receptor in guinea pig cerebellumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetKappa-type opioid receptor(Guinea pig)
Mercachem

Curated by ChEMBL
LigandPNGBDBM50325534(nalfurafine | CHEMBL267495)
Affinity DataKi:  0.225nMAssay Description:Displacement of [3H]U69593 from kappa opioid receptor in guinea pig cerebellumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetKappa-type opioid receptor(Guinea pig)
Mercachem

Curated by ChEMBL
LigandPNGBDBM50325534(nalfurafine | CHEMBL267495)
Affinity DataKi:  0.225nMAssay Description:Displacement of [3H]U69593 from kappa opioid receptor in guinea pig cerebellumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetKappa-type opioid receptor(Human)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50325534(nalfurafine | CHEMBL267495)
Affinity DataKi:  0.230nMAssay Description:Binding affinity to kappa opioid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetKappa-type opioid receptor(Human)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50325534(nalfurafine | CHEMBL267495)
Affinity DataKi:  0.230nMAssay Description:Binding affinity to kappa opioid receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetDelta-type opioid receptor(Rat)
Mercachem

Curated by ChEMBL
LigandPNGBDBM50325534(nalfurafine | CHEMBL267495)
Affinity DataKi:  0.370nMAssay Description:Displacement of [3H]-DPDPE from delta opioid receptor in rat brain membrane after 120 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2016
Entry Details Article
PubMed
TargetMu-type opioid receptor(Guinea pig)
Mercachem

Curated by ChEMBL
LigandPNGBDBM50325534(nalfurafine | CHEMBL267495)
Affinity DataKi:  0.390nMAssay Description:Displacement of [3H]-DAMGO from mu opioid receptor in guinea pig brain membrane after 120 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2016
Entry Details Article
PubMed
TargetMu-type opioid receptor(Mouse)
Kitasato University

Curated by ChEMBL
LigandPNGBDBM50325534(nalfurafine | CHEMBL267495)
Affinity DataKi:  0.430nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor in mouse brain membranes without cerebellumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2016
Entry Details Article
PubMed
TargetMu-type opioid receptor(Guinea pig)
Mercachem

Curated by ChEMBL
LigandPNGBDBM50325534(nalfurafine | CHEMBL267495)
Affinity DataKi:  0.582nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor in guinea pig forebrainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetMu-type opioid receptor(Guinea pig)
Mercachem

Curated by ChEMBL
LigandPNGBDBM50325534(nalfurafine | CHEMBL267495)
Affinity DataKi:  0.582nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor in guinea pig forebrainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Kitasato University

Curated by ChEMBL
LigandPNGBDBM50325534(nalfurafine | CHEMBL267495)
Affinity DataKi:  0.700nMAssay Description:Displacement of [3H]DAMGO from human MOR expressed in HEK293 cell membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetDelta-type opioid receptor(Human)
Kitasato University

Curated by ChEMBL
LigandPNGBDBM50325534(nalfurafine | CHEMBL267495)
Affinity DataKi:  37nMAssay Description:Displacement of [3H]U-69-593 from human DOR expressed in HEK293 cell membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetDelta-type opioid receptor(Mouse)
Kitasato University

Curated by ChEMBL
LigandPNGBDBM50325534(nalfurafine | CHEMBL267495)
Affinity DataKi:  51nMAssay Description:Displacement of [3H]DPDPE from delta opioid receptor in mouse brain membranes without cerebellumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2016
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50325534(nalfurafine | CHEMBL267495)
Affinity DataKi:  170nMAssay Description:Binding affinity to kappa opioid receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)