BDBM50249679 CHEMBL447069::edotecarin

SMILES OCC(CO)NN1C(=O)c2c(C1=O)c1c3ccc(O)cc3n(O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)c1c1[nH]c3cc(O)ccc3c21

InChI Key InChIKey=LOOUCKLUDHIJPN-UHFFFAOYSA-N

Data  1 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50249679   

TargetEpidermal growth factor receptor(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50249679(edotecarin | CHEMBL447069)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of EGFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50249679(edotecarin | CHEMBL447069)
Affinity DataEC50:  100nMAssay Description:Inhibition of human DNA topoisomerase 1-mediated DNA cleavage assessed as relaxation of supercoiled pBR322 plasmid DNA after 15 mins by densitometerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Mouse)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50249679(edotecarin | CHEMBL447069)
Affinity DataEC50:  1.5nMAssay Description:Inhibition of DNA topoisomerase 1 in mouse P388/S cells assessed as formation of topoisomerase 1-DNA complex by proteinase K/SDS methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed