BDBM50164648 2'-deoxythymidine triphosphate::5'-TTP::CHEMBL363559::dTTP::dThd5'PPP::deoxy-TTP::pppdT::thymidine 5'-(tetrahydrogen triphosphate)::thymidine 5'-triphosphate

SMILES CC1=CN(C(=O)NC1=O)[C@H]2C[C@@H]([C@H](O2)CO[P@](=O)(O)O[P@@](=O)(O)OP(=O)(O)O)O

InChI Key InChIKey=NHVNXKFIZYSCEB-UHFFFAOYSA-N

Data  1 KI  1 IC50  9 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50164648   

TargetDNA polymerase beta(Human)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50164648(thymidine 5'-(tetrahydrogen triphosphate) | dTTP |...)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of human DNA polymerase-betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2019
Entry Details Article
PubMed
TargetReverse transcriptase(Human immunodeficiency virus type 1)
University of Pittsburgh School of Medicine

Curated by ChEMBL
LigandPNGBDBM50164648(thymidine 5'-(tetrahydrogen triphosphate) | dTTP |...)
Affinity DataKd:  2.20E+3nMAssay Description:Binding affinity to HIV1 reverse transcriptaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed
TargetReverse transcriptase(Human immunodeficiency virus type 1)
University of Pittsburgh School of Medicine

Curated by ChEMBL
LigandPNGBDBM50164648(thymidine 5'-(tetrahydrogen triphosphate) | dTTP |...)
Affinity DataKd:  2.08E+3nMAssay Description:Binding affinity to wild type HIV1 LAI reverse transcriptaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetReverse transcriptase protein(Human immunodeficiency virus type 1)
University of Pittsburgh School of Medicine

Curated by ChEMBL
LigandPNGBDBM50164648(thymidine 5'-(tetrahydrogen triphosphate) | dTTP |...)
Affinity DataKd:  1.20E+3nMAssay Description:Binding affinity to HIV1 LAI reverse transcriptase M41L/L210W/T215Y mutantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetReverse transcriptase protein(Human immunodeficiency virus type 1)
University of Pittsburgh School of Medicine

Curated by ChEMBL
LigandPNGBDBM50164648(thymidine 5'-(tetrahydrogen triphosphate) | dTTP |...)
Affinity DataKd:  2.65E+3nMAssay Description:Binding affinity to HIV1 LAI reverse transcriptase M41L/L210W/T215Y/M184V mutantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetReverse transcriptase protein(Human immunodeficiency virus type 1)
University of Pittsburgh School of Medicine

Curated by ChEMBL
LigandPNGBDBM50164648(thymidine 5'-(tetrahydrogen triphosphate) | dTTP |...)
Affinity DataKd:  2.85E+3nMAssay Description:Binding affinity to HIV1 LAI reverse transcriptase M184V mutantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetReverse transcriptase(Human immunodeficiency virus type 1)
University of Pittsburgh School of Medicine

Curated by ChEMBL
LigandPNGBDBM50164648(thymidine 5'-(tetrahydrogen triphosphate) | dTTP |...)
Affinity DataKd:  6.71E+4nMAssay Description:Inhibition of RNA-dependent DNA polymerase activity of HIV 1 reverse transcriptase assessed as incorporation of dTMP by burst assay using RNA/DNA Pri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed
TargetReverse transcriptase protein(Human immunodeficiency virus type 1)
University of Pittsburgh School of Medicine

Curated by ChEMBL
LigandPNGBDBM50164648(thymidine 5'-(tetrahydrogen triphosphate) | dTTP |...)
Affinity DataKd:  1.44E+5nMAssay Description:Inhibition of RNA-dependent DNA polymerase activity of HIV 1 reverse transcriptase M184V mutant assessed as incorporation of dTMP by burst assay usin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed
TargetReverse transcriptase protein(Human immunodeficiency virus type 1)
University of Pittsburgh School of Medicine

Curated by ChEMBL
LigandPNGBDBM50164648(thymidine 5'-(tetrahydrogen triphosphate) | dTTP |...)
Affinity DataKd:  7.32E+4nMAssay Description:Inhibition of DNA-dependent DNA polymerase activity of HIV 1 reverse transcriptase M184V mutant assessed as incorporation of dTMP by burst assay usin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed
TargetReverse transcriptase(Human immunodeficiency virus type 1)
University of Pittsburgh School of Medicine

Curated by ChEMBL
LigandPNGBDBM50164648(thymidine 5'-(tetrahydrogen triphosphate) | dTTP |...)
Affinity DataKd:  1.54E+4nMAssay Description:Inhibition of DNA-dependent DNA polymerase activity of HIV 1 reverse transcriptase assessed as incorporation of dTMP by burst assay using DNA/DNA Pri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Biota

Curated by ChEMBL
LigandPNGBDBM50164648(thymidine 5'-(tetrahydrogen triphosphate) | dTTP |...)
Affinity DataKi:  61nMAssay Description:Inhibitory constant against HIV-1 reverse transcriptaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed