BDBM50056922 1,4-Dihydroxy-10-methoxy-5,8-dimethyl-3,7-dioxo-1,3-dihydro-7H-benzo[e]furo[3',4':3,4]benzo[b][1,4]dioxepine-11-carbaldehyde::CHEMBL173530::NSC-87511::Stictic acid::Stictic acid (StA), 1::cid_73677

SMILES COc1cc(C)c2c(Oc3c4C(O)OC(=O)c4c(O)c(C)c3OC2=O)c1C=O

InChI Key InChIKey=SKCUFZLDTAYNBZ-UHFFFAOYSA-N

Data  13 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50056922   

LigandPNGBDBM50056922(cid_73677 | CHEMBL173530 | 1,4-Dihydroxy-10-methox...)
Affinity DataIC50: 8.50E+4nMAssay Description:Project Title: A screen for modulators of human Rad51, a key DNA repair protein Application Number: MH084119 Assay Submitter: Dr. Alex Mazin Submitte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/31/2011
Entry Details
PCBioAssay
LigandPNGBDBM50056922(cid_73677 | CHEMBL173530 | 1,4-Dihydroxy-10-methox...)
Affinity DataIC50: 8.74E+3nMAssay Description:Project Title: A screen for modulators of human Rad51, a key DNA repair protein Application Number: MH084119 Assay Submitter: Dr. Alex Mazin Submitte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2011
Entry Details
PCBioAssay
TargetM1 family aminopeptidase(Plasmodium falciparum (isolate FcB1 / Columbia))
Srmlsc

Curated by PubChem BioAssay
LigandPNGBDBM50056922(cid_73677 | CHEMBL173530 | 1,4-Dihydroxy-10-methox...)
Affinity DataIC50: 2.73E+4nMAssay Description:Southern Research Molecular Libraries Screening Center (SRMLSC) Southern Research Institute (Birmingham, Alabama) NIH Molecular Libraries Screening...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2011
Entry Details
PCBioAssay
TargetSerine/threonine-protein kinase 33(Human)
Broad Institute

Curated by PubChem BioAssay
LigandPNGBDBM50056922(cid_73677 | CHEMBL173530 | 1,4-Dihydroxy-10-methox...)
Affinity DataEC50:  3.20E+4nMAssay Description:Keywords: STK33 Kinase, Non-ATP Competitive Inhibitor Assay Overview: Purified STK33 Kinase is preincubated with potential inhibitors and allowed to ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2011
Entry Details
PCBioAssay
TargetDual specificity mitogen-activated protein kinase kinase 6(Human)
Yale University School of Medicine

LigandPNGBDBM50056922(cid_73677 | CHEMBL173530 | 1,4-Dihydroxy-10-methox...)
Affinity DataIC50: 2.40E+4nMAssay Description:The labeled fragment can be distinguished from full-length MKK by a change in fluorescence polarization. MKK6 was used as a substrate because it cou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2012
Entry Details Article
PubMed
Target3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ [1-175](Yersinia pestis)
Brookhaven National Laboratory

LigandPNGBDBM50056922(cid_73677 | CHEMBL173530 | 1,4-Dihydroxy-10-methox...)
Affinity DataIC50: 1.30E+4nMpH: 7.0 T: 2°CAssay Description:The enzymatic activities of FtFabZ and YpFabZ were determined via the reportedspectrophotometric method using the substrate analogue crotonoyl-CoA.7 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2016
Entry Details Article
PubMed
Target3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ(Francisella tularensis)
Brookhaven National Laboratory

LigandPNGBDBM50056922(cid_73677 | CHEMBL173530 | 1,4-Dihydroxy-10-methox...)
Affinity DataIC50: 2.78E+4nMpH: 7.0 T: 2°CAssay Description:The enzymatic activities of FtFabZ and YpFabZ were determined via the reportedspectrophotometric method using the substrate analogue crotonoyl-CoA.7 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2016
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50056922(cid_73677 | CHEMBL173530 | 1,4-Dihydroxy-10-methox...)
Affinity DataIC50: 4.40E+3nMAssay Description:Inhibitory concentration of compound against 3'-processing of HIV-1 integrase in experiment 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2012
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50056922(cid_73677 | CHEMBL173530 | 1,4-Dihydroxy-10-methox...)
Affinity DataIC50: 1.17E+4nMAssay Description:Inhibitory concentration of compound against disintegration (reversal of strand transfer)of HIV-1 integraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2012
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50056922(cid_73677 | CHEMBL173530 | 1,4-Dihydroxy-10-methox...)
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibitory concentration of compound against strand transfer of HIV-1 integrase in experiment 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2012
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50056922(cid_73677 | CHEMBL173530 | 1,4-Dihydroxy-10-methox...)
Affinity DataIC50: 2.90E+3nMAssay Description:Inhibitory concentration of compound against 3'-processing of HIV-1 integrase in experiment 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2012
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50056922(cid_73677 | CHEMBL173530 | 1,4-Dihydroxy-10-methox...)
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibitory concentration of compound against strand transfer of HIV-1 integrase in experiment 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2012
Entry Details Article
PubMed
TargetRho guanine nucleotide exchange factor 1(Human)
Paris-Saclay University

Curated by ChEMBL
LigandPNGBDBM50056922(cid_73677 | CHEMBL173530 | 1,4-Dihydroxy-10-methox...)
Affinity DataIC50: 1.87E+5nMAssay Description:Inhibition of p115 DHPH22 domain (395 to 766 residues) (unknown origin) interaction with GDP-loaded His-tagged RhoA F25N mutant (1 to 180 residues) a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
Target14 kDa phosphohistidine phosphatase(Human)
University of Utah College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50056922(cid_73677 | CHEMBL173530 | 1,4-Dihydroxy-10-methox...)
Affinity DataIC50: 2.20E+4nMAssay Description:Inhibition of PHPT1 (unknown origin) using DiFMUP as fluorogenic substrate incubated for 30 mins followed by substrate addition and measured every 60...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed