BDBM50322743 8-chloro-N-(3-morpholinopropyl)-5H-pyrimido[5,4-b]indol-4-amine::CHEMBL597857::GNF-Pf-4478::cid_661700

SMILES Clc1ccc2[nH]c3c(NCCCN4CCOCC4)ncnc3c2c1

InChI Key InChIKey=ULJISGNQAXNPOC-UHFFFAOYSA-N

Data  1 KI  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50322743   

TargetInsulin-degrading enzyme(Human)
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM50322743(cid_661700 | CHEMBL597857 | GNF-Pf-4478 | 8-chloro...)
Affinity DataIC50: 1.09E+4nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/1/2011
Entry Details
PCBioAssay
TargetMethionine--tRNA ligase(Trypanosoma brucei brucei (strain 927/4 GUTat10.1))
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM50322743(cid_661700 | CHEMBL597857 | GNF-Pf-4478 | 8-chloro...)
Affinity DataIC50: 9.10E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2013
Entry Details
PCBioAssay
TargetCruzipain(Trypanosoma cruzi)
Universidade Federal De Minas Gerais

Curated by ChEMBL
LigandPNGBDBM50322743(cid_661700 | CHEMBL597857 | GNF-Pf-4478 | 8-chloro...)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of recombinant Trypanosoma cruzi cruzain using Z-phe-Arg-amidomethylcoumarin as substrate by fluorometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/31/2019
Entry Details Article
PubMed
TargetCruzipain(Trypanosoma cruzi)
Universidade Federal De Minas Gerais

Curated by ChEMBL
LigandPNGBDBM50322743(cid_661700 | CHEMBL597857 | GNF-Pf-4478 | 8-chloro...)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of Trypanosoma cruzi CruzainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetCruzipain(Trypanosoma cruzi)
Universidade Federal De Minas Gerais

Curated by ChEMBL
LigandPNGBDBM50322743(cid_661700 | CHEMBL597857 | GNF-Pf-4478 | 8-chloro...)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of Trypanosoma cruzi CruzainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetCruzipain(Trypanosoma cruzi)
Universidade Federal De Minas Gerais

Curated by ChEMBL
LigandPNGBDBM50322743(cid_661700 | CHEMBL597857 | GNF-Pf-4478 | 8-chloro...)
Affinity DataKi:  2.00E+3nMAssay Description:Inhibition of Trypanosoma cruzi cruzain assessed as Z-Phe-Arg-aminomethylcoumarin cleavage by competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2010
Entry Details Article
PubMed