BDBM55436 2-(phenylmethyl)-4,5-dihydro-1H-imidazole;hydrochloride::2-Benzyl-4,5-dihydro-1H-imidazole::2-benzyl-2-imidazoline;hydrochloride::2-benzyl-4,5-dihydro-1H-imidazole;hydrochloride::MLS000559484::SMR000149600::Tolazoline::cid_6048

SMILES C(C1=NCCN1)c1ccccc1

InChI Key InChIKey=JIVZKJJQOZQXQB-UHFFFAOYSA-N

Data  20 KI  6 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 28 hits for monomerid = 55436   

TargetNeutrophil cytosol factor 1 [S99G](Human)
Emory University

Curated by PubChem BioAssay
LigandPNGBDBM55436(Tolazoline | SMR000149600 | MLS000559484 | cid_604...)
Affinity DataIC50: 5.00E+4nMAssay Description:NIH Molecular Libraries Screening Centers Network [MLSCN] Emory Chemical Biology Discovery Center in MLSCN Assay provider: Susan Smith, Emory Univers...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/7/2011
Entry Details
PCBioAssay
TargetBile salt export pump(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM55436(Tolazoline | SMR000149600 | MLS000559484 | cid_604...)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2019
Entry Details Article
PubMed
LigandPNGBDBM55436(Tolazoline | SMR000149600 | MLS000559484 | cid_604...)
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of specific [3H]-prazosin binding (0.2 nM) to rat brain membranes alpha1 adrenoceptor; 2.1*10e-6More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2012
Entry Details Article
PubMed
LigandPNGBDBM55436(Tolazoline | SMR000149600 | MLS000559484 | cid_604...)
Affinity DataIC50: 280nMAssay Description:Inhibition of specific [3H]-clonidine binding (0.4 nM) to rat brain membranes alpha-2 adrenoceptor; 2.8*10e-7More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2012
Entry Details Article
PubMed
TargetGuanine nucleotide-binding protein subunit alpha-15(Human)
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM55436(Tolazoline | SMR000149600 | MLS000559484 | cid_604...)
Affinity DataIC50: 2.99E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2013
Entry Details
PCBioAssay
TargetTrace amine-associated receptor 1(Human)
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM55436(Tolazoline | SMR000149600 | MLS000559484 | cid_604...)
Affinity DataEC50:  1.01E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2013
Entry Details
PCBioAssay
TargetTrace amine-associated receptor 1(Human)
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM55436(Tolazoline | SMR000149600 | MLS000559484 | cid_604...)
Affinity DataIC50: 4.74E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2013
Entry Details
PCBioAssay
TargetGuanine nucleotide-binding protein subunit alpha-15(Human)
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM55436(Tolazoline | SMR000149600 | MLS000559484 | cid_604...)
Affinity DataEC50: >2.99E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2013
Entry Details
PCBioAssay
TargetAlpha-2A adrenergic receptor(Human)
University of Nebraska

Curated by PDSP Ki Database
LigandPNGBDBM55436(Tolazoline | SMR000149600 | MLS000559484 | cid_604...)
Affinity DataKi:  24nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2011
Entry Details
PubMed
TargetAlpha-2B adrenergic receptor(Rat)
University of Nebraska

Curated by PDSP Ki Database
LigandPNGBDBM55436(Tolazoline | SMR000149600 | MLS000559484 | cid_604...)
Affinity DataKi:  113nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2011
Entry Details
PubMed
TargetAlpha-2C adrenergic receptor(Rat)
Janssen Pharmaceutica

Curated by PDSP Ki Database
LigandPNGBDBM55436(Tolazoline | SMR000149600 | MLS000559484 | cid_604...)
Affinity DataKi:  120nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2011
Entry Details Article
PubMed
LigandPNGBDBM55436(Tolazoline | SMR000149600 | MLS000559484 | cid_604...)
Affinity DataKi:  180nMAssay Description:Displacement of [3H]clonidine from Alpha-2 adrenergic receptor of rat brain membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2018
Entry Details Article
PubMed
LigandPNGBDBM55436(Tolazoline | SMR000149600 | MLS000559484 | cid_604...)
Affinity DataKi:  180nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2011
Entry Details
PubMed
TargetAlpha-2C adrenergic receptor(OK)
University of Nebraska

Curated by PDSP Ki Database
LigandPNGBDBM55436(Tolazoline | SMR000149600 | MLS000559484 | cid_604...)
Affinity DataKi:  222nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2011
Entry Details
PubMed
TargetAlpha-2A adrenergic receptor(Human)
University of Nebraska

Curated by PDSP Ki Database
LigandPNGBDBM55436(Tolazoline | SMR000149600 | MLS000559484 | cid_604...)
Affinity DataKi:  229nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2012
Entry Details Article
PubMed
TargetAlpha-2C adrenergic receptor(Rat)
Janssen Pharmaceutica

Curated by PDSP Ki Database
LigandPNGBDBM55436(Tolazoline | SMR000149600 | MLS000559484 | cid_604...)
Affinity DataKi:  450nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2011
Entry Details Article
PubMed
TargetAlpha-2C adrenergic receptor(Rat)
Janssen Pharmaceutica

Curated by PDSP Ki Database
LigandPNGBDBM55436(Tolazoline | SMR000149600 | MLS000559484 | cid_604...)
Affinity DataKi:  500nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2011
Entry Details Article
PubMed
TargetAlpha-2C adrenergic receptor(Rat)
Janssen Pharmaceutica

Curated by PDSP Ki Database
LigandPNGBDBM55436(Tolazoline | SMR000149600 | MLS000559484 | cid_604...)
Affinity DataKi:  890nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2011
Entry Details Article
PubMed
TargetTrace amine-associated receptor 1(Human)
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM55436(Tolazoline | SMR000149600 | MLS000559484 | cid_604...)
Affinity DataKi:  1.64E+3nMAssay Description:Displacement of (S)-4-(2,4-difluorophenyl-3-tritio) -4,5-dihydro-2-oxazolamine from human TAAR1 receptor expressed in HEK293 cells after 90 mins by b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM55436(Tolazoline | SMR000149600 | MLS000559484 | cid_604...)
Affinity DataKi:  2.00E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2011
Entry Details Article
PubMed
LigandPNGBDBM55436(Tolazoline | SMR000149600 | MLS000559484 | cid_604...)
Affinity DataKi:  2.10E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2011
Entry Details
PubMed
TargetAlpha-2B adrenergic receptor(Human)
Roche Bioscience

Curated by PDSP Ki Database
LigandPNGBDBM55436(Tolazoline | SMR000149600 | MLS000559484 | cid_604...)
Affinity DataKi:  3.16E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2012
Entry Details Article
PubMed
LigandPNGBDBM55436(Tolazoline | SMR000149600 | MLS000559484 | cid_604...)
Affinity DataKi:  3.20E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2011
Entry Details Article
PubMed
TargetAlpha-2C adrenergic receptor(Human)
Roche Bioscience

Curated by PDSP Ki Database
LigandPNGBDBM55436(Tolazoline | SMR000149600 | MLS000559484 | cid_604...)
Affinity DataKi:  3.72E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1B(Human)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM55436(Tolazoline | SMR000149600 | MLS000559484 | cid_604...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity towards human 5-hydroxytryptamine 1B receptor using [3H]5-HT trifluoroacetate as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM55436(Tolazoline | SMR000149600 | MLS000559484 | cid_604...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity towards human 5-hydroxytryptamine 1D receptor using [3H]5-HT trifluoroacetate as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM55436(Tolazoline | SMR000149600 | MLS000559484 | cid_604...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity towards human 5-hydroxytryptamine 1D receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1B(Human)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM55436(Tolazoline | SMR000149600 | MLS000559484 | cid_604...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity towards human 5-hydroxytryptamine 1B receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed