BDBM22879 (1R)-1-(4-tert-butylphenyl)-4-[4-(hydroxydiphenylmethyl)piperidin-1-yl]butan-1-ol::(1R)-1-(4-tert-butylphenyl)-4-{4-[hydroxy(diphenyl)methyl]piperidin-1-yl}butan-1-ol::(R)-(+)-Terfenadine::Terfenadine::cid_5405

SMILES CC(C)(C)c1ccc(cc1)[C@H](O)CCCN1CCC(CC1)C(O)(c1ccccc1)c1ccccc1

InChI Key InChIKey=GUGOEEXESWIERI-UHFFFAOYSA-N

Data  3 KI  5 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 22879   

TargetDNA damage-inducible transcript 3 protein(Mouse)
Emory University

Curated by PubChem BioAssay
LigandPNGBDBM22879((1R)-1-(4-tert-butylphenyl)-4-[4-(hydroxydiphenylm...)
Affinity DataIC50: 1.00E+4nMAssay Description:NIH Molecular Libraries Screening Centers Network [MLSCN] Emory Chemical Biology Discovery Center in MLSCN Assay provider: Dr. Randal Kaufman, Univer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2011
Entry Details
PCBioAssay
TargetX-box-binding protein 1(Human)
Emory University

Curated by PubChem BioAssay
LigandPNGBDBM22879((1R)-1-(4-tert-butylphenyl)-4-[4-(hydroxydiphenylm...)
Affinity DataIC50: 5.10E+3nMAssay Description:NIH Molecular Libraries Screening Centers Network [MLSCN] Emory Chemical Biology Discovery Center in MLSCN Assay provider: Dr. Randal Kaufman, Univer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2011
Entry Details
PCBioAssay
TargetDNA damage-inducible transcript 3 protein(Mouse)
Emory University

Curated by PubChem BioAssay
LigandPNGBDBM22879((1R)-1-(4-tert-butylphenyl)-4-[4-(hydroxydiphenylm...)
Affinity DataIC50: 1.00E+4nMAssay Description:NIH Molecular Libraries Screening Centers Network [MLSCN] Emory Chemical Biology Discovery Center in MLSCN Assay provider: Dr. Randal Kaufman, Univer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2011
Entry Details
PCBioAssay
TargetUbiquitin-conjugating enzyme E2 N(Human)
Burnham Center For Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM22879((1R)-1-(4-tert-butylphenyl)-4-[4-(hydroxydiphenylm...)
Affinity DataIC50: 2.00E+4nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego CA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2011
Entry Details
PCBioAssay
TargetHistamine H1 receptor(Guinea pig)
TBA

Curated by ChEMBL
LigandPNGBDBM22879((1R)-1-(4-tert-butylphenyl)-4-[4-(hydroxydiphenylm...)
Affinity DataKd:  380nMAssay Description:Inhibition of specific binding of [3H]mepyramine to Histamine 1 receptors in guinea-pigMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2013
Entry Details Article

TargetATP-dependent translocase ABCB1(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM22879((1R)-1-(4-tert-butylphenyl)-4-[4-(hydroxydiphenylm...)
Affinity DataIC50: 1.40E+3nMAssay Description:TP_TRANSPORTER: inhibition of Calcein-AM efflux in MDR1-expressing LLC-PK1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
Ucb Pharma

Curated by PDSP Ki Database
LigandPNGBDBM22879((1R)-1-(4-tert-butylphenyl)-4-[4-(hydroxydiphenylm...)
In Depth
Date in BDB:
5/3/2012
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
Ucb Pharma

Curated by PDSP Ki Database
LigandPNGBDBM22879((1R)-1-(4-tert-butylphenyl)-4-[4-(hydroxydiphenylm...)
Affinity DataKi:  3.16nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2012
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Vrije Universiteit Amsterdam

LigandPNGBDBM22879((1R)-1-(4-tert-butylphenyl)-4-[4-(hydroxydiphenylm...)
Affinity DataKi: >1.00E+4nM ΔG°: >-7.09kcal/molepH: 7.4 T: 2°CAssay Description:Ligand displacement assays were performed on The SK-N-MC/hH4R cell homogenates. Retained radioactivity was determined by liquid scintillation countin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2008
Entry Details Article
PubMed