BDBM50015144 2-(4-Butoxy-phenyl)-N-hydroxy-acetamide::Bufexamac::CHEMBL94394::cid_2466

SMILES CCCCOc1ccc(cc1)CC(=O)NO

InChI Key InChIKey=MXJWRABVEGLYDG-UHFFFAOYSA-N

Data  5 IC50  1 Kd  1 EC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50015144   

TargetM1 family aminopeptidase(Plasmodium falciparum (isolate FcB1 / Columbia))
Srmlsc

Curated by PubChem BioAssay
LigandPNGBDBM50015144(cid_2466 | 2-(4-Butoxy-phenyl)-N-hydroxy-acetamide...)
Affinity DataIC50: 8.12E+4nMAssay Description:Southern Research Molecular Libraries Screening Center (SRMLSC) Southern Research Institute (Birmingham, Alabama) NIH Molecular Libraries Screening...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2011
Entry Details
PCBioAssay
TargetM17 leucyl aminopeptidase(Plasmodium falciparum (isolate 3D7))
Srmlsc

Curated by PubChem BioAssay
LigandPNGBDBM50015144(cid_2466 | 2-(4-Butoxy-phenyl)-N-hydroxy-acetamide...)
Affinity DataIC50: 1.00E+3nMAssay Description:Southern Research Molecular Libraries Screening Center (SRMLSC) Southern Research Institute (Birmingham, Alabama) NIH Molecular Libraries Screening...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2011
Entry Details
PCBioAssay
TargetHeat shock factor protein 1(Mouse)
Broad Institute

Curated by PubChem BioAssay
LigandPNGBDBM50015144(cid_2466 | 2-(4-Butoxy-phenyl)-N-hydroxy-acetamide...)
Affinity DataEC50: >1.95E+5nMAssay Description:Keywords: Heat Shock Factor-1 (HSF-1), Stress Response, MG132, NIH3T3, Luminescence Assay Overview: Modified NIH3T3, transformed to express firefly...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2011
Entry Details
PCBioAssay
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50015144(cid_2466 | 2-(4-Butoxy-phenyl)-N-hydroxy-acetamide...)
Affinity DataIC50: 129nMAssay Description:Logarithmic value of inhibitory concentration against 5-lipoxygenase in rat basophilic leukemia cells (RBL-1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-lipoxygenase(Bovine)
WestfäLische Wilhelms-UniversitäT MüNster

Curated by ChEMBL
LigandPNGBDBM50015144(cid_2466 | 2-(4-Butoxy-phenyl)-N-hydroxy-acetamide...)
Affinity DataIC50: 3.50E+4nMAssay Description:5-LO inhibitory activity, measured by production of 5-hydroxyeicosatetraenoic acid (5-HETE) and leukotriene B4 (LTB4) in bovine polymorphonuclear leu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHistone deacetylase 3(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50015144(cid_2466 | 2-(4-Butoxy-phenyl)-N-hydroxy-acetamide...)
Affinity DataKd:  3.41E+5nMAssay Description:Inhibition of HDAC3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50015144(cid_2466 | 2-(4-Butoxy-phenyl)-N-hydroxy-acetamide...)
Affinity DataIC50: 2.70E+4nMAssay Description:In vitro inhibitory activity against 5-lipoxygenase in rat basophilic leukemia cells(RBL-1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed