BDBM50102456 Ac-D-Nal-[D-(pCl)Phe]-D-Pal-Ser-[Aph(Ac)]-D-[Aph(Ac)]-Leu-ILys-Pro-DAla-NH2::CHEMBL262747::acyline

SMILES CC(C)C[C@H](NC(=O)[C@@H](Cc1ccc(NC(C)=O)cc1)NC(=O)[C@H](Cc1ccc(NC(C)=O)cc1)NC(=O)[C@H](CO)NC(=O)[C@@H](Cc1cccnc1)NC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(C)=O)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O

InChI Key InChIKey=ZWNUQDJANZGVFO-UHFFFAOYSA-N

Data  4 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50102456   

TargetGonadotropin-releasing hormone receptor(Rat)
Salk Institute

Curated by ChEMBL
LigandPNGBDBM50102456(acyline | Ac-D-Nal-[D-(pCl)Phe]-D-Pal-Ser-[Aph(Ac)...)
Affinity DataIC50: 1.5nMAssay Description:Antagonist activity at rat GnRHR expressed in HEK293 cells assessed as inhibition of GnRH-induced luciferase response by reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Human)
Salk Institute

Curated by ChEMBL
LigandPNGBDBM50102456(acyline | Ac-D-Nal-[D-(pCl)Phe]-D-Pal-Ser-[Aph(Ac)...)
Affinity DataIC50: 0.520nMAssay Description:Antagonist activity at human GnRHR expressed in HEK293 cells assessed as inhibition of GnRH-induced luciferase response by reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Human)
Salk Institute

Curated by ChEMBL
LigandPNGBDBM50102456(acyline | Ac-D-Nal-[D-(pCl)Phe]-D-Pal-Ser-[Aph(Ac)...)
Affinity DataIC50: 6.80nMAssay Description:Antagonism of human GnHR receptor, determined in a reporter gene assay in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Human)
Salk Institute

Curated by ChEMBL
LigandPNGBDBM50102456(acyline | Ac-D-Nal-[D-(pCl)Phe]-D-Pal-Ser-[Aph(Ac)...)
Affinity DataIC50: 0.690nMAssay Description:Antagonist activity at human GnRH receptor expressed in HEK293 cells as inhibition of GnRH-induced LH secretion by reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2012
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Human)
Salk Institute

Curated by ChEMBL
LigandPNGBDBM50102456(acyline | Ac-D-Nal-[D-(pCl)Phe]-D-Pal-Ser-[Aph(Ac)...)
Affinity DataKd:  2.51nMAssay Description:Competitive antagonism of GnRH-induced response in the reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed