BDBM517718 US11124489, Entry 33::ZL0682

SMILES Clc1cc(Cl)cc(NNC(C#N)C(=O)c2ccc3ccccc3c2)c1

InChI Key InChIKey=WAKQODCWKHJBPH-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 517718   

TargetRap guanine nucleotide exchange factor 3(Human)
University Of Texas

US Patent
LigandPNGBDBM517718(ZL0682 | US11124489, Entry 33)
Affinity DataIC50: 1.13E+4nMAssay Description:To explore the SARs and examine how the modifications on the isoxazole ring affect biological activities of newly synthesized analogues, we first eva...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2022
Entry Details
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TargetRap guanine nucleotide exchange factor 4(Human)
University Of Texas

US Patent
LigandPNGBDBM517718(ZL0682 | US11124489, Entry 33)
Affinity DataIC50: 2.50E+3nMAssay Description:From the biological results discussed above, compounds 10, 14-15, 23-24, 26-27, and 31-32 were identified as potent EPAC1 inhibitors with IC50 values...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2022
Entry Details
Go to US Patent