BDBM50527778 KPT-330::Selinexor::US20240376114, Compound 70::Xpovio

SMILES FC(F)(F)c1cc(cc(c1)C(F)(F)F)-c1ncn(\C=C/C(=O)NNc2cnccn2)n1

InChI Key InChIKey=DEVSOMFAQLZNKR-UHFFFAOYSA-N

Data  3 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50527778   

TargetExportin-1(Human)
Dalian University of Technology

Curated by ChEMBL
LigandPNGBDBM50527778(KPT-330 | Selinexor | Xpovio | US20240376114, Comp...)
Affinity DataKd:  19nMAssay Description:Binding affinity to recombinant His-tagged CRM1 (unknown origin) by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetExportin-1(Human)
Dalian University of Technology

Curated by ChEMBL
LigandPNGBDBM50527778(KPT-330 | Selinexor | Xpovio | US20240376114, Comp...)
Affinity DataIC50: 34nMAssay Description:Inhibition of XPO1 in human MOLT-16 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetExportin-1(Human)
Dalian University of Technology

Curated by ChEMBL
LigandPNGBDBM50527778(KPT-330 | Selinexor | Xpovio | US20240376114, Comp...)
Affinity DataIC50: 55nMAssay Description:Inhibition of XPO1 in human HPBALL cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetProtein Rev(Human immunodeficiency virus type 1)
Karyopharm Therapeutics

US Patent
LigandPNGBDBM50527778(KPT-330 | Selinexor | Xpovio | US20240376114, Comp...)
Affinity DataIC50: 1.00E+3nMAssay Description:The ability of exemplary compounds of the invention to inhibit CRM1-mediated nuclear export was assessed in a RevGFP assay. Rev is a protein from hum...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2025
Entry Details
Go to US Patent