BDBM50375813 CHEMBL428402::XR-9577

SMILES O=C(Nc1ccccc1C(=O)Nc1ccc(CCN2CCc3ccccc3C2)cc1)c1cnc2ccccc2c1

InChI Key InChIKey=JCKRZMGEVAGHHV-UHFFFAOYSA-N

Data  18 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 50375813   

TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Human)
Rheinische Friedrich-Wilhelms-Universit£T Bonn

Curated by ChEMBL
LigandPNGBDBM50375813(XR-9577 | CHEMBL428402)
Affinity DataIC50: 704nMAssay Description:Inhibition of recombinant human GFP-fused ABCG2 expressed in MDCK2 cells assessed as reduction in Hoechst 33342 efflux preincubated for 30 mins follo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2018
Entry Details Article
PubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Human)
Rheinische Friedrich-Wilhelms-Universit£T Bonn

Curated by ChEMBL
LigandPNGBDBM50375813(XR-9577 | CHEMBL428402)
Affinity DataIC50: 704nMAssay Description:Inhibition of human ABCG2 expressed in MDCK2 cells assessed as reduction in Hoechst 33342 efflux pre-incubated for 30 mins before Hoechst 33342 addit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Human)
Rheinische Friedrich-Wilhelms-Universit£T Bonn

Curated by ChEMBL
LigandPNGBDBM50375813(XR-9577 | CHEMBL428402)
Affinity DataIC50: 741nMAssay Description:Inhibition of human ABCG2 expressed in MDCK2 cells assessed as reduction in pheophorbide A efflux pre-incubated for 30 mins before Hoechst 33342 addi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Human)
Rheinische Friedrich-Wilhelms-Universit£T Bonn

Curated by ChEMBL
LigandPNGBDBM50375813(XR-9577 | CHEMBL428402)
Affinity DataIC50: 741nMAssay Description:Inhibition of c-terminal GFP-tagged human ABCG2 expressed in MDCK2 cells preincubated for 30 mins before Pheophorbide A addition by Pheophorbide A as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Human)
Rheinische Friedrich-Wilhelms-Universit£T Bonn

Curated by ChEMBL
LigandPNGBDBM50375813(XR-9577 | CHEMBL428402)
Affinity DataIC50: 741nMAssay Description:Inhibition of c-terminal GFP-tagged human ABCG2 expressed in MDCK2 cells preincubated for 30 mins before Pheophorbide A addition by Pheophorbide A as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Human)
Rheinische Friedrich-Wilhelms-Universit£T Bonn

Curated by ChEMBL
LigandPNGBDBM50375813(XR-9577 | CHEMBL428402)
Affinity DataIC50: 704nMAssay Description:Inhibition of c-terminal GFP-tagged human ABCG2 expressed in MDCK2 cells preincubated for 30 mins before Hoechst 33342 addition by Hoechst 33342 accu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Human)
Rheinische Friedrich-Wilhelms-Universit£T Bonn

Curated by ChEMBL
LigandPNGBDBM50375813(XR-9577 | CHEMBL428402)
Affinity DataIC50: 704nMAssay Description:Inhibition of c-terminal GFP-tagged human ABCG2 expressed in MDCK2 cells preincubated for 30 mins before Hoechst 33342 addition by Hoechst 33342 accu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Human)
Rheinische Friedrich-Wilhelms-Universit£T Bonn

Curated by ChEMBL
LigandPNGBDBM50375813(XR-9577 | CHEMBL428402)
Affinity DataIC50: 704nMAssay Description:Inhibition of C-terminal GFP-fused human ABCG2 expressed in MDCK2 cells preincubated for 30 mins followed by Hoechst 33342 addition and measured ever...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Human)
Rheinische Friedrich-Wilhelms-Universit£T Bonn

Curated by ChEMBL
LigandPNGBDBM50375813(XR-9577 | CHEMBL428402)
Affinity DataIC50: 741nMAssay Description:Inhibition of recombinant human GFP-fused ABCG2 expressed in MDCK2 cells assessed as reduction in pheophorbide A efflux preincubated for 30 mins foll...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2018
Entry Details Article
PubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Human)
Rheinische Friedrich-Wilhelms-Universit£T Bonn

Curated by ChEMBL
LigandPNGBDBM50375813(XR-9577 | CHEMBL428402)
Affinity DataIC50: 721nMAssay Description:Inhibition of GFP-tagged human BCRP expressed in MDCK2 cells pre-incubated for 30 mins followed by Hoechst 33342 addition and further incubated for 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/6/2016
Entry Details Article
PubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Human)
Rheinische Friedrich-Wilhelms-Universit£T Bonn

Curated by ChEMBL
LigandPNGBDBM50375813(XR-9577 | CHEMBL428402)
Affinity DataIC50: 676nMAssay Description:Inhibition of ABCG2 in human mitoxantrone-resistant MCF7 cells by Hoechst 33342 assay using one phase exponential association analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Human)
Rheinische Friedrich-Wilhelms-Universit£T Bonn

Curated by ChEMBL
LigandPNGBDBM50375813(XR-9577 | CHEMBL428402)
Affinity DataIC50: 832nMAssay Description:Inhibition of ABCG2 in human mitoxantrone-resistant MCF7 cells by Hoechst 33342 assay using linear regression analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Human)
Rheinische Friedrich-Wilhelms-Universit£T Bonn

Curated by ChEMBL
LigandPNGBDBM50375813(XR-9577 | CHEMBL428402)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of ABCG2 in human mitoxantrone-resistant MCF7 cells by Hoechst 33342 assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50375813(XR-9577 | CHEMBL428402)
Affinity DataIC50: 447nMAssay Description:Inhibition of human Pgp in A2780 cells after 30 mins by calcein AM assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50375813(XR-9577 | CHEMBL428402)
Affinity DataIC50: 355nMAssay Description:Inhibition of human Pgp in A2780 cells after 30 mins by Hoechst 33342 assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Mouse)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50375813(XR-9577 | CHEMBL428402)
Affinity DataIC50: 320nMAssay Description:Inhibition of mouse Pgp in EMT6/AR1.0 cells after 1 hr by daunorubicin accumulation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50375813(XR-9577 | CHEMBL428402)
Affinity DataIC50: 355nMAssay Description:Inhibition of P-glycoprotein by Hoechst assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50375813(XR-9577 | CHEMBL428402)
Affinity DataIC50: 490nMAssay Description:Inhibition of P-glycoprotein expressed in A2780/ADR cells by calcein AM assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed