BDBM209859 4-N-(5-cyclopropyl-1H-pyrazol-3-yl)-6-(4-methylpiperazin-1-yl)-2-N-[(3-propan-2-yl-1,2-oxazol-5-yl)methyl]pyrimidine-2,4-diamine::XL-228

SMILES CC(C)c1cc(CNc2nc(Nc3cc([nH]n3)C3CC3)cc(n2)N2CCN(C)CC2)on1

InChI Key InChIKey=ALKJNCZNEOTEMP-UHFFFAOYSA-N

Data  4 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 209859   

TargetEphrin type-A receptor 2 [596-900](Human)
Technical University of Munich

LigandPNGBDBM209859(XL-228 | 4-N-(5-cyclopropyl-1H-pyrazol-3-yl)-6-(4-...)
Affinity DataKd:  19nMAssay Description:Kinobeads competition assays were performed in 96-well format as previously described using mixed protein lysates of four cancer cell lines (K-562, M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2017
Entry Details Article
PubMed
TargetEphrin type-A receptor 2 [596-900](Human)
Technical University of Munich

LigandPNGBDBM209859(XL-228 | 4-N-(5-cyclopropyl-1H-pyrazol-3-yl)-6-(4-...)
Affinity DataIC50: 4nMAssay Description:Refer to Reaction Biology Corps.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2017
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Hangzhou Medical College

Curated by ChEMBL
LigandPNGBDBM209859(XL-228 | 4-N-(5-cyclopropyl-1H-pyrazol-3-yl)-6-(4-...)
Affinity DataIC50: 14nMAssay Description:Inhibition of Abl T315I mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Hangzhou Medical College

Curated by ChEMBL
LigandPNGBDBM209859(XL-228 | 4-N-(5-cyclopropyl-1H-pyrazol-3-yl)-6-(4-...)
Affinity DataIC50: 5nMAssay Description:Inhibition of wild type Abl (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetAurora kinase A(Human)
Hangzhou Medical College

Curated by ChEMBL
LigandPNGBDBM209859(XL-228 | 4-N-(5-cyclopropyl-1H-pyrazol-3-yl)-6-(4-...)
Affinity DataIC50: 3.10nMAssay Description:Inhibition of Aurora A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed