BDBM50045698 1-Cyclopropyl-7-(2,6-dimethyl-pyridin-4-yl)-6,8-difluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid::CHEMBL8179::WIN-57294

SMILES Cc1cc(cc(C)n1)-c1c(F)cc2c(c1F)n(cc(C(O)=O)c2=O)C1CC1

InChI Key InChIKey=WHXJSJBKDGZVDA-UHFFFAOYSA-N

Data  6 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50045698   

TargetDNA topoisomerase 2-beta(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50045698(WIN-57294 | 1-Cyclopropyl-7-(2,6-dimethyl-pyridin-...)
Affinity DataEC50: >5.40E+4nMAssay Description:Inhibition of calf thymus DNA/ethidium bromide complex formation.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2012
Entry Details Article

LigandPNGBDBM50045698(WIN-57294 | 1-Cyclopropyl-7-(2,6-dimethyl-pyridin-...)
Affinity DataEC50:  7.60E+3nMAssay Description:Inhibitory activity against HeLa cell Topoisomerase IIMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2018
Entry Details

LigandPNGBDBM50045698(WIN-57294 | 1-Cyclopropyl-7-(2,6-dimethyl-pyridin-...)
Affinity DataEC50:  7.60E+3nMAssay Description:Inhibitory activity in a cell-free assay of DNA cleavage mediated by purified HeLa cell topoisomerase II.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2018
Entry Details

LigandPNGBDBM50045698(WIN-57294 | 1-Cyclopropyl-7-(2,6-dimethyl-pyridin-...)
Affinity DataEC50:  7.60E+3nMAssay Description:Compound was tested for topoisomerase II inhibition in purified HeLa cells by SDS/K+ precipitation methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2012
Entry Details Article

LigandPNGBDBM50045698(WIN-57294 | 1-Cyclopropyl-7-(2,6-dimethyl-pyridin-...)
Affinity DataEC50:  7.60E+3nMAssay Description:Tested for inhibition of topoisomerase II isolated from HeLa cells by DNA-cleavage assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2019
Entry Details Article
PubMed
LigandPNGBDBM50045698(WIN-57294 | 1-Cyclopropyl-7-(2,6-dimethyl-pyridin-...)
Affinity DataEC50:  7.60E+3nMAssay Description:Inhibitory activity in a DNA cleavage assay using HeLa DNA topoisomerase II yielding its effective concentrationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed