BDBM50248764 2-bromo-4-(6,7-dimethoxyquinazolin-4-ylamino)phenol::CHEMBL473773::WHI-P154

SMILES COc1cc2ncnc(Nc3ccc(O)c(Br)c3)c2cc1OC

InChI Key InChIKey=CBIAKDAYHRWZCU-UHFFFAOYSA-N

Data  3 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50248764   

TargetTyrosine-protein kinase JAK2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50248764(WHI-P154 | 2-bromo-4-(6,7-dimethoxyquinazolin-4-yl...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of JAK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50248764(WHI-P154 | 2-bromo-4-(6,7-dimethoxyquinazolin-4-yl...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of JAK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Universitaire Vaudois

Curated by ChEMBL
LigandPNGBDBM50248764(WHI-P154 | 2-bromo-4-(6,7-dimethoxyquinazolin-4-yl...)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of JAK3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Human)
Rheinische Friedrich-Wilhelms-University of Bonn

Curated by ChEMBL
LigandPNGBDBM50248764(WHI-P154 | 2-bromo-4-(6,7-dimethoxyquinazolin-4-yl...)
Affinity DataEC50:  189nMAssay Description:Inhibition of ABCG2 (unknown origin) expressed in MDCK2 cells co-expressing BCRP (unknown origin) assessed as potentiation of SN-38-induced cytotoxic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Rheinische Friedrich-Wilhelms-University of Bonn

Curated by ChEMBL
LigandPNGBDBM50248764(WHI-P154 | 2-bromo-4-(6,7-dimethoxyquinazolin-4-yl...)
Affinity DataEC50:  3.08E+3nMAssay Description:Inhibition of ABCB1 in human A2780/ADR cells assessed as potentiation of daunorubicin-induced cytotoxicity measured after 72 hrs by MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed