BDBM50375827 CHEMBL407848::WAY-255348

SMILES Cn1c(ccc1-c1cc2c(NC(=O)C2(C)C)c(F)c1)C#N

InChI Key InChIKey=KIOOLNRTWPFVHX-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50375827   

TargetProgesterone receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50375827(WAY-255348 | CHEMBL407848)
Affinity DataIC50: 4.10nMAssay Description:Displacement of [3H]R5020 from human PR in human T47D cells by whole cell assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50375827(WAY-255348 | CHEMBL407848)
Affinity DataIC50: 196nMAssay Description:Antagonist activity at human AR ligand binding domain expressed in african green monkey COS7 cells in presence of 5-alpha-dihydrotestosterone by Gal4...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50375827(WAY-255348 | CHEMBL407848)
Affinity DataIC50: 3.70E+3nMAssay Description:Antagonist activity at human MR ligand binding domain expressed in african green monkey COS7 cells in presence of aldosterone by Gal4 hybrid assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50375827(WAY-255348 | CHEMBL407848)
Affinity DataIC50: 5nMAssay Description:Antagonist activity at human PR expressed in human T47D cells assessed as inhibition of progesterone induced alkaline phosphataseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed