BDBM50088373 CHEBI:46295::Vardenafil::cid_110634

SMILES CCCc1nc(c2n1NC(=NC2=O)c3cc(ccc3OCC)S(=O)(=O)N4CCN(CC4)CC)C

InChI Key InChIKey=SECKRCOLJRRGGV-UHFFFAOYSA-N

Data  1 KI  15 IC50  1 EC50

PDB links: 5 PDB IDs match this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 50088373   

TargetSodium channel protein type 5 subunit alpha(Human)
University of Oxford

Curated by ChEMBL

LigandBDBM50088373(CHEBI:46295 | Vardenafil | cid_110634)Copy SMILESCopy InChI

Affinity DataIC50: 2.51E+6nMAssay Description:Inhibition of fast sodium current (INa) in Chinese Hamster Ovary (CHO) K1 cells transfected with human Nav1.5 measured using IonWorks Quattro automat...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseChEBI
DrugBankPC cidPC sidPDBSimilars

In Depth
Date in BDB:
5/7/2016
Entry Details Article
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TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Endotherm

Curated by ChEMBL

LigandBDBM50088373(CHEBI:46295 | Vardenafil | cid_110634)Copy SMILESCopy InChI

Affinity DataIC50: 0.0290nMAssay Description:Inhibition of human platelets derived PDE5 using [3H]-cGMP as substrate incubated for 60 min by scintillation proximity assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseChEBI
DrugBankPC cidPC sidPDBSimilars

In Depth
Date in BDB:
3/26/2022
Entry Details Article
Copy Entry DOIPubMedPDB3D Structure (crystal)
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TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Endotherm

Curated by ChEMBL

LigandBDBM50088373(CHEBI:46295 | Vardenafil | cid_110634)Copy SMILESCopy InChI

Affinity DataIC50: 0.501nMAssay Description:Inhibition of PDE5 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseChEBI
DrugBankPC cidPC sidPDBSimilars

In Depth
Date in BDB:
8/16/2020
Entry Details Article
Copy Entry DOIPubMedPDB3D Structure (crystal)
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TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Endotherm

Curated by ChEMBL

LigandBDBM50088373(CHEBI:46295 | Vardenafil | cid_110634)Copy SMILESCopy InChI

Affinity DataIC50: 0.890nMAssay Description:Inhibition of PDE5A (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseChEBI
DrugBankPC cidPC sidPDBSimilars

In Depth
Date in BDB:
8/16/2020
Entry Details Article
Copy Entry DOIPubMedPDB3D Structure (crystal)
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TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Endotherm

Curated by ChEMBL

LigandBDBM50088373(CHEBI:46295 | Vardenafil | cid_110634)Copy SMILESCopy InChI

Affinity DataIC50: 0.170nMAssay Description:Inhibition of PDE5A1 (unknwon origin) using [3H]cGMP as substrate after 30 mins by SPAMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseChEBI
DrugBankPC cidPC sidPDBSimilars

In Depth
Date in BDB:
11/2/2019
Entry Details Article
Copy Entry DOIPubMedPDB3D Structure (crystal)
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TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Endotherm

Curated by ChEMBL

LigandBDBM50088373(CHEBI:46295 | Vardenafil | cid_110634)Copy SMILESCopy InChI

Affinity DataIC50: 0.890nMAssay Description:Inhibition of recombinant human PDE5AMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseChEBI
DrugBankPC cidPC sidPDBSimilars

In Depth
Date in BDB:
7/12/2018
Entry Details Article
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TargetPotassium voltage-gated channel subfamily E/KQT member 1(Human)
University of Oxford

Curated by ChEMBL

LigandBDBM50088373(CHEBI:46295 | Vardenafil | cid_110634)Copy SMILESCopy InChI

Affinity DataIC50: 6.31E+5nMAssay Description:Inhibition of slow delayed inward rectifying potassium current (Iks) in Chinese Hamster Ovary (CHO) cells expressing hKvLQT1/hminK measured using Ion...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseChEBI
DrugBankPC cidPC sidPDBSimilars

In Depth
Date in BDB:
5/7/2016
Entry Details Article
Copy Entry DOIPubMed
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TargetPotassium voltage-gated channel subfamily H member 2(Human)
University of Oxford

Curated by ChEMBL

LigandBDBM50088373(CHEBI:46295 | Vardenafil | cid_110634)Copy SMILESCopy InChI

Affinity DataIC50: 7.94E+4nMAssay Description:Inhibition of rapid delayed inward rectifying potassium current (IKr) in Chinese hamster ovary (CHO) cells stable expressing hERG measured using IonW...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProtUniProtKB/TrEMBL
GoogleScholar

Ligand InfoPurchaseChEBI
DrugBankPC cidPC sidPDBSimilars

In Depth
Date in BDB:
5/7/2016
Entry Details Article
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TargetCystic fibrosis transmembrane conductance regulator(Human)
Southern Research Institute

Curated by PubChem BioAssay

LigandBDBM50088373(CHEBI:46295 | Vardenafil | cid_110634)Copy SMILESCopy InChI

Affinity DataIC50: 140nMMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseChEBI
DrugBankPC cidPC sidPDBSimilars

In Depth
Date in BDB:
11/9/2016
Entry Details
Copy Entry DOIPCBioAssay
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TargetPotassium voltage-gated channel subfamily H member 2(Human)
University of Oxford

Curated by ChEMBL

LigandBDBM50088373(CHEBI:46295 | Vardenafil | cid_110634)Copy SMILESCopy InChI

Affinity DataIC50: 3.16E+4nMAssay Description:Inhibition of rapid delayed inward rectifying potassium current (IKr) measured using manual patch clamp assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProtUniProtKB/TrEMBL
GoogleScholar

Ligand InfoPurchaseChEBI
DrugBankPC cidPC sidPDBSimilars

In Depth
Date in BDB:
5/7/2016
Entry Details Article
Copy Entry DOIPubMed
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TargetPotassium voltage-gated channel subfamily D member 3(Human)
University of Oxford

Curated by ChEMBL

LigandBDBM50088373(CHEBI:46295 | Vardenafil | cid_110634)Copy SMILESCopy InChI

Affinity DataIC50: 7.94E+4nMAssay Description:Inhibition of transient outward potassium current (Ito) current in Chinese Hamster Ovary (CHO) K1 cells expressing human Kv4.3 measured using IonWork...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseChEBI
DrugBankPC cidPC sidPDBSimilars

In Depth
Date in BDB:
5/7/2016
Entry Details Article
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TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Human)
University of Oxford

Curated by ChEMBL

LigandBDBM50088373(CHEBI:46295 | Vardenafil | cid_110634)Copy SMILESCopy InChI

Affinity DataIC50: 2.51E+5nMAssay Description:Inhibition of long-lasting type calcium current (ICaL) in HEK293 cells (alpha1C/beta2a/alpha2delta1) cells measured using IonWorks Barracuda automat...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseChEBI
DrugBankPC cidPC sidPDBSimilars

In Depth
Date in BDB:
5/7/2016
Entry Details Article
Copy Entry DOIPubMed
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TargetSodium channel protein type 5 subunit alpha(Human)
University of Oxford

Curated by ChEMBL

LigandBDBM50088373(CHEBI:46295 | Vardenafil | cid_110634)Copy SMILESCopy InChI

Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of fast sodium current (INa) in HEK293 cells transfected with human Nav1.5 measured using IonWorks Quattro automated patch clamp platformMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseChEBI
DrugBankPC cidPC sidPDBSimilars

In Depth
Date in BDB:
5/7/2016
Entry Details Article
Copy Entry DOIPubMed
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TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Human)
University of Oxford

Curated by ChEMBL

LigandBDBM50088373(CHEBI:46295 | Vardenafil | cid_110634)Copy SMILESCopy InChI

Affinity DataIC50: 1.58E+4nMAssay Description:Inhibition of long-lasting type calcium current (hICa) in Chinese Hamster Ovary (CHO) cells expressing hCav1.2 measured using IonWorks Quattro automa...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseChEBI
DrugBankPC cidPC sidPDBSimilars

In Depth
Date in BDB:
5/7/2016
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL

TargetPotassium voltage-gated channel subfamily H member 2(Human)
University of Oxford

Curated by ChEMBL

LigandBDBM50088373(CHEBI:46295 | Vardenafil | cid_110634)Copy SMILESCopy InChI

Affinity DataIC50: 3.16E+5nMAssay Description:Inhibition of rapid delayed inward rectifying potassium current (IKr) in Chinese hamster ovary (CHO) K1 cells stably expressing hERG measured using I...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProtUniProtKB/TrEMBL
GoogleScholar

Ligand InfoPurchaseChEBI
DrugBankPC cidPC sidPDBSimilars

In Depth
Date in BDB:
5/7/2016
Entry Details Article
Copy Entry DOIPubMed
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TargetCystic fibrosis transmembrane conductance regulator(Human)
Southern Research Institute

Curated by PubChem BioAssay

LigandBDBM50088373(CHEBI:46295 | Vardenafil | cid_110634)Copy SMILESCopy InChI

Affinity DataEC50: >5.00E+4nMMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseChEBI
DrugBankPC cidPC sidPDBSimilars

In Depth
Date in BDB:
11/9/2016
Entry Details
Copy Entry DOIPCBioAssay
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TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Endotherm

Curated by ChEMBL

LigandBDBM50088373(CHEBI:46295 | Vardenafil | cid_110634)Copy SMILESCopy InChI

Affinity DataKi:  0.700nMAssay Description:Inhibition of PDE5 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseChEBI
DrugBankPC cidPC sidPDBSimilars

In Depth
Date in BDB:
8/18/2020
Entry Details Article
Copy Entry DOIPubMedPDB3D Structure (crystal)
Copy Rxn URL