BDBM50258439 1-(4-bromobenzyl)indoline-2,3-dione::CHEMBL523685::CVD-0005886::LOR-NEU-c8f11034-5::VU0119498::cid_3008304

SMILES Brc1ccc(CN2C(=O)C(=O)c3ccccc23)cc1

InChI Key InChIKey=DELLOEULSHGYCG-UHFFFAOYSA-N

Data  3 IC50  17 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 20 hits for monomerid = 50258439   

TargetMuscarinic acetylcholine receptor M2(Human)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50258439(cid_3008304 | CHEMBL523685 | VU0119498 | 1-(4-brom...)
Affinity DataEC50: >3.00E+4nMAssay Description:Positive allosteric modulation of muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as effect on acetylcholine-induced intrac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Cornell University

LigandPNGBDBM50258439(cid_3008304 | CHEMBL523685 | VU0119498 | 1-(4-brom...)
Affinity DataIC50: 1.98E+5nMAssay Description:Compounds were seeded into assay-ready plates (Greiner 384 low volume, cat. no. 784900) using an Echo 555 acoustic dispenser, and dimethyl sulfoxide ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2023
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Cornell University

LigandPNGBDBM50258439(cid_3008304 | CHEMBL523685 | VU0119498 | 1-(4-brom...)
Affinity DataIC50: 1.98E+5nMAssay Description:Compounds were seeded into assay-ready plates (Greiner 384 low volume, cat 784900) using an Echo 555 acoustic dispenser, and DMSO was back-filled for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2021
Entry Details Article

TargetReplicase polyprotein 1ab(2019-nCoV)
Cornell University

LigandPNGBDBM50258439(cid_3008304 | CHEMBL523685 | VU0119498 | 1-(4-brom...)
Affinity DataIC50: 747nMAssay Description:The assay was performed according to the published procedure. Briefly, compounds were seeded into assay-ready plates (Greiner 384PP, cat# 781280) usi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2021
Entry Details Article

TargetMuscarinic acetylcholine receptor M3(Human)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50258439(cid_3008304 | CHEMBL523685 | VU0119498 | 1-(4-brom...)
Affinity DataEC50:  6.40E+3nMAssay Description:Positive allosteric modulation activity at muscarinic M3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50258439(cid_3008304 | CHEMBL523685 | VU0119498 | 1-(4-brom...)
Affinity DataEC50:  6.00E+3nMAssay Description:Positive allosteric modulation activity at muscarinic M1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M5(Human)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50258439(cid_3008304 | CHEMBL523685 | VU0119498 | 1-(4-brom...)
Affinity DataEC50:  4.10E+3nMAssay Description:Positive allosteric modulation activity at muscarinic M5 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M5(Human)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50258439(cid_3008304 | CHEMBL523685 | VU0119498 | 1-(4-brom...)
Affinity DataEC50:  4.60E+3nMAssay Description:Positive allosteric modulation of muscarinic M5 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium mob...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M4(Human)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50258439(cid_3008304 | CHEMBL523685 | VU0119498 | 1-(4-brom...)
Affinity DataEC50: >3.00E+4nMAssay Description:Positive allosteric modulation of muscarinic M4 receptor expressed in CHO cells co-expressing Gqi5 assessed as effect on acetylcholine-induced intrac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M3(Human)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50258439(cid_3008304 | CHEMBL523685 | VU0119498 | 1-(4-brom...)
Affinity DataEC50:  6.40E+3nMAssay Description:Positive allosteric modulation of muscarinic M3 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium mob...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Rat)
Vanderbilt Screening Center For Gpcrs, Ion Channels and Transporters

Curated by PubChem BioAssay
LigandPNGBDBM50258439(cid_3008304 | CHEMBL523685 | VU0119498 | 1-(4-brom...)
Affinity DataEC50:  6.04E+3nMAssay Description:Assay Provider: P. Jeffrey Conn Assay Provider Affiliation: Vanderbilt University Muscarinic acetylcholine receptors are family A GPCRs comprised of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2011
Entry Details
PCBioAssay
TargetMuscarinic acetylcholine receptor M1(Human)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50258439(cid_3008304 | CHEMBL523685 | VU0119498 | 1-(4-brom...)
Affinity DataEC50:  6.10E+3nMAssay Description:Positive allosteric modulation of muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium mob...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M5(Human)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50258439(cid_3008304 | CHEMBL523685 | VU0119498 | 1-(4-brom...)
Affinity DataEC50:  4.10E+3nMAssay Description:Agonist activity at human muscarinic M5 expressed in CHO cells assessed as stimulation of calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M4(Rat)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50258439(cid_3008304 | CHEMBL523685 | VU0119498 | 1-(4-brom...)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at rat muscarinic M4 expressed in CHO cells assessed as stimulation of calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M3(Human)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50258439(cid_3008304 | CHEMBL523685 | VU0119498 | 1-(4-brom...)
Affinity DataEC50:  6.40E+3nMAssay Description:Agonist activity at human muscarinic M3 expressed in CHO cells assessed as stimulation of calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M2(Rat)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50258439(cid_3008304 | CHEMBL523685 | VU0119498 | 1-(4-brom...)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at rat muscarinic M2 expressed in CHO cells assessed as stimulation of calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Rat)
Vanderbilt Screening Center For Gpcrs, Ion Channels and Transporters

Curated by PubChem BioAssay
LigandPNGBDBM50258439(cid_3008304 | CHEMBL523685 | VU0119498 | 1-(4-brom...)
Affinity DataEC50:  6.10E+3nMAssay Description:Agonist activity at rat muscarinic M1 expressed in CHO cells assessed as stimulation of calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M5(Human)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50258439(cid_3008304 | CHEMBL523685 | VU0119498 | 1-(4-brom...)
Affinity DataEC50:  4.08E+3nMAssay Description:Activation of human muscarinic M5 receptor expressed in CHO cells coexpressing Gq protein assessed as potentiation of acetylcholine-induced intracell...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M3(Human)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50258439(cid_3008304 | CHEMBL523685 | VU0119498 | 1-(4-brom...)
Affinity DataEC50:  6.38E+3nMAssay Description:Activation of human muscarinic M3 receptor expressed in CHO cells coexpressing Gq protein assessed as potentiation of acetylcholine-induced intracell...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Rat)
Vanderbilt Screening Center For Gpcrs, Ion Channels and Transporters

Curated by PubChem BioAssay
LigandPNGBDBM50258439(cid_3008304 | CHEMBL523685 | VU0119498 | 1-(4-brom...)
Affinity DataEC50:  6.04E+3nMAssay Description:Activation of rat muscarinic M1 receptor expressed in CHO cells co-expressing Gq protein assessed as potentiation of acetylcholine-induced intracellu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed