BDBM50559854 Motolimod::VTX-2337::VTX-378

SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)-c1ccc(cc1)C(=O)N1CCCC1

InChI Key InChIKey=QSPOQCXMGPDIHI-UHFFFAOYSA-N

Data  5 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50559854   

TargetToll-like receptor 8(Human)
University of Montpellier

Curated by ChEMBL
LigandPNGBDBM50559854(Motolimod | VTX-2337 | VTX-378)
Affinity DataEC50:  100nMAssay Description:Agonist activity at TLR8 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetToll-like receptor 8(Human)
University of Montpellier

Curated by ChEMBL
LigandPNGBDBM50559854(Motolimod | VTX-2337 | VTX-378)
Affinity DataEC50:  1.30E+3nMAssay Description:Agonist activity at TLR8 in human cryopreserved PBMC assessed as inhibition of IL-12p40 production measured after 24 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetToll-like receptor 7(Human)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50559854(Motolimod | VTX-2337 | VTX-378)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at TLR7 in human cryopreserved PBMC assessed as induction of IFNalpha production measured after 24 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetToll-like receptor 8(Human)
University of Montpellier

Curated by ChEMBL
LigandPNGBDBM50559854(Motolimod | VTX-2337 | VTX-378)
Affinity DataEC50:  100nMAssay Description:Agonist activity at human TLR8 expressed in HEK293 cells by reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetToll-like receptor 8(Human)
University of Montpellier

Curated by ChEMBL
LigandPNGBDBM50559854(Motolimod | VTX-2337 | VTX-378)
Affinity DataEC50:  100nMAssay Description:Agonist activity at TLR8 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed