BDBM50553404 CPI-444::Ciforadenant::V-81444::V81444

SMILES Cc1ccc(o1)-c1nc(N)nc2n(Cc3cccc(CO[C@H]4CCOC4)n3)nnc12

InChI Key InChIKey=KURQKNMKCGYWRJ-UHFFFAOYSA-N

Data  5 KI  5 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50553404   

TargetAdenosine receptor A2a(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50553404(Ciforadenant | V81444 | CPI-444 | V-81444)
Affinity DataIC50: 17nMAssay Description:Antagonist activity at human adenosine 2A receptor expressed in HEK293 cells assessed as inhibition of NECA-induced cAMP by immunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50553404(Ciforadenant | V81444 | CPI-444 | V-81444)
Affinity DataIC50: 70nMAssay Description:Antagonist activity at adenosine 2A receptor in human T cells assessed as inhibition of cAMP incubated for 10 mins by Eu-cAMP tracer based TR-FRET as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50553404(Ciforadenant | V81444 | CPI-444 | V-81444)
Affinity DataEC50: >1.00E+4nMAssay Description:Antagonist activity at adenosine 2A receptor (unknown origin) in presence of high adenosineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50553404(Ciforadenant | V81444 | CPI-444 | V-81444)
Affinity DataIC50: 87nMAssay Description:Antagonist activity at human A2aR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 60 mins by ultra LANCE cAMP detect...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50553404(Ciforadenant | V81444 | CPI-444 | V-81444)
Affinity DataIC50: 87nMAssay Description:Antagonist activity at human A2aR expressed in HEK293 cells assessed as reduction in NECA-induced cAMP production incubated for 20 mins in presence o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50553404(Ciforadenant | V81444 | CPI-444 | V-81444)
Affinity DataIC50: 3.35E+3nMAssay Description:Antagonist activity at human A2aR expressed in HEK293 cells assessed as reduction in NECA-induced cAMP production incubated for 20 mins in presence o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50553404(Ciforadenant | V81444 | CPI-444 | V-81444)
Affinity DataKi:  3.40nMAssay Description:Displacement of [3H]CGS-21680 from human adenosine 2A receptor expressed in HEK293 cells incubated for 90 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50553404(Ciforadenant | V81444 | CPI-444 | V-81444)
Affinity DataKi:  3.40nMAssay Description:Antagonist activity at adenosine A2A receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetAdenosine receptor A1(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50553404(Ciforadenant | V81444 | CPI-444 | V-81444)
Affinity DataKi:  192nMAssay Description:Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in CHO-K1 cells incubated for 90 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetAdenosine receptor A3(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50553404(Ciforadenant | V81444 | CPI-444 | V-81444)
Affinity DataKi:  2.50E+3nMAssay Description:Displacement of [125I]-AB MECA from human adenosine A3 receptor expressed in CHO-K1 cells incubated for 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetAdenosine receptor A2b(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50553404(Ciforadenant | V81444 | CPI-444 | V-81444)
Affinity DataKi:  3.98E+3nMAssay Description:Displacement of [3H]-ZM241385 from human adenosine 2B receptor expressed in HEK-293 cells incubated for 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed