BDBM50128581 Biphenyl-3-yl-carbamic acid cyclohexyl ester::CHEMBL77767::URB602::biphenyl-3-ylcarbamic acid cyclohexyl ester::cyclohexyl biphenyl-3-ylcarbamate

SMILES O=C(Nc1cccc(c1)-c1ccccc1)OC1CCCCC1

InChI Key InChIKey=HHVUFQYJOSFTEH-UHFFFAOYSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50128581   

TargetMonoglyceride lipase(Rat)
University of California Irvine

LigandPNGBDBM50128581(cyclohexyl biphenyl-3-ylcarbamate | CHEMBL77767 | ...)
Affinity DataIC50: 2.23E+5nMpH: 8.0Assay Description:The measurement of the ability of URB602 compound to inhibit MGL activity. More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/4/2011
Entry Details Article
PubMed
TargetFatty-acid amide hydrolase 1 [30-579](Rat)
Università

Curated by ChEMBL
LigandPNGBDBM50128581(cyclohexyl biphenyl-3-ylcarbamate | CHEMBL77767 | ...)
Affinity DataIC50: 3.00E+4nMAssay Description:Fatty acid amide hydrolase inhibitory activity in rat brain membrane using [3H]anandamide as a substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMonoglyceride lipase(Human)
Louvain Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50128581(cyclohexyl biphenyl-3-ylcarbamate | CHEMBL77767 | ...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human MGLMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetFatty-acid amide hydrolase 1(Human)
Louvain Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50128581(cyclohexyl biphenyl-3-ylcarbamate | CHEMBL77767 | ...)
Affinity DataIC50: 5.65E+3nMAssay Description:Inhibition of human FAAHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetMonoglyceride lipase(Rat)
University of California Irvine

LigandPNGBDBM50128581(cyclohexyl biphenyl-3-ylcarbamate | CHEMBL77767 | ...)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of MAGL in Wistar rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetFatty-acid amide hydrolase 1(Human)
Louvain Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50128581(cyclohexyl biphenyl-3-ylcarbamate | CHEMBL77767 | ...)
Affinity DataIC50: 5.75E+3nMAssay Description:Inhibition of human recombinant FAAH-maltose binding proteinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetMonoglyceride lipase(Human)
Louvain Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50128581(cyclohexyl biphenyl-3-ylcarbamate | CHEMBL77767 | ...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human MGL activity using [3H]2-oleoylglycerol substrate by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetMonoglyceride lipase(Rat)
University of California Irvine

LigandPNGBDBM50128581(cyclohexyl biphenyl-3-ylcarbamate | CHEMBL77767 | ...)
Affinity DataIC50: 2.80E+4nMAssay Description:Inhibition of MAGL from Wistar rat brain using 2-monooleoyl[1,2,3-H]glycerol as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2019
Entry Details Article
PubMed
TargetMonoglyceride lipase(Rat)
University of California Irvine

LigandPNGBDBM50128581(cyclohexyl biphenyl-3-ylcarbamate | CHEMBL77767 | ...)
Affinity DataIC50: 2.80E+4nMAssay Description:Inhibition of Wistar rat MAGL using 2-monooleoyl[1,2,3-3H]glycerol as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetMonoglyceride lipase(Human)
Louvain Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50128581(cyclohexyl biphenyl-3-ylcarbamate | CHEMBL77767 | ...)
Affinity DataIC50: 9.10E+3nMAssay Description:Inhibition of recombinant human MAGL using 7-HRA as substrate preincubated for 60 mins followed by substrate addition by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetMonoglyceride lipase(Mouse)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50128581(cyclohexyl biphenyl-3-ylcarbamate | CHEMBL77767 | ...)
Affinity DataIC50: 1.98E+4nMAssay Description:Inhibition of MAGL in mouse B16-F10 cells using 7-HRA as substrate preincubated for 60 mins followed by substrate addition measured every 2.5 mins fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetMonoglyceride lipase(Human)
Louvain Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50128581(cyclohexyl biphenyl-3-ylcarbamate | CHEMBL77767 | ...)
Affinity DataIC50: 2.80E+4nMAssay Description:Inhibition of MAGL (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed