BDBM50349866 CHEMBL160296::CHEMBL1813590::UNC10108016::US9156822, 39

SMILES COc1ccccc1N1CCN(CCCCOc2ccc3CCC(=O)Nc3c2)CC1

InChI Key InChIKey=HVSUPPZVIPTMEM-UHFFFAOYSA-N

Data  6 KI  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50349866   

TargetD(2) dopamine receptor(Human)
University of North Carolina At Chapel Hill

US Patent
LigandPNGBDBM50349866(CHEMBL1813590 | CHEMBL160296 | UNC10108016 | US915...)
Affinity DataEC50:  0.5nMpH: 7.4Assay Description:Recruitment of β-arrestin to agonist-stimulated D2 receptors was performed using a previously described Tango-type assay (Barnea et al., Proc. N...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2016
Entry Details
Go to US Patent

TargetD(2) dopamine receptor(Human)
University of North Carolina At Chapel Hill

US Patent
LigandPNGBDBM50349866(CHEMBL1813590 | CHEMBL160296 | UNC10108016 | US915...)
Affinity DataEC50:  2.5nMAssay Description:Partial agonist activity at human D2L receptor expressed in HEK293T cells coexpressing Gi subunit assessed as inhibition of isoproterenol-stimulated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
University of North Carolina At Chapel Hill

US Patent
LigandPNGBDBM50349866(CHEMBL1813590 | CHEMBL160296 | UNC10108016 | US915...)
Affinity DataEC50:  0.600nMAssay Description:Partial agonist activity at D2L receptor in human HTLA cells assessed as beta arrestin recruitment at 6 uM after 18 hrs by luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
University of North Carolina At Chapel Hill

US Patent
LigandPNGBDBM50349866(CHEMBL1813590 | CHEMBL160296 | UNC10108016 | US915...)
Affinity DataKi:  0.220nMAssay Description:Displacement of [125I]ABN from human recombinant D2L receptor expressed in HEK cells after 60 mins by gamma counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
University of North Carolina At Chapel Hill

US Patent
LigandPNGBDBM50349866(CHEMBL1813590 | CHEMBL160296 | UNC10108016 | US915...)
Affinity DataKi:  0.300nMAssay Description:Displacement of [3H]N-methylspiperone from human D2L receptor expressed in CHO cells after 1.5 hrs by microbeta counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
University of North Carolina At Chapel Hill

US Patent
LigandPNGBDBM50349866(CHEMBL1813590 | CHEMBL160296 | UNC10108016 | US915...)
Affinity DataKi:  0.320nMpH: 7.4Assay Description:Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2016
Entry Details
Go to US Patent

TargetD(3) dopamine receptor(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50349866(CHEMBL1813590 | CHEMBL160296 | UNC10108016 | US915...)
Affinity DataKi:  13.1nMAssay Description:Displacement of [125I]ABN from human recombinant D3 receptor expressed in HEK cells after 60 mins by gamma counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetD(4) dopamine receptor(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50349866(CHEMBL1813590 | CHEMBL160296 | UNC10108016 | US915...)
Affinity DataKi:  212nMAssay Description:Displacement of [125I]ABN from human recombinant D4 receptor expressed in HEK cells after 60 mins by gamma counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
Washington University

Curated by ChEMBL
LigandPNGBDBM50349866(CHEMBL1813590 | CHEMBL160296 | UNC10108016 | US915...)
Affinity DataKi:  1.18E+3nMAssay Description:Displacement of [3H](+)-pentazocine from guinea pig brain sigma-1 receptor after 90 mins by liquid scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed