BDBM210930 UCP1173

SMILES CCc1nc(N)nc(N)c1C#C[C@H](C)c1cc(OC)cc(c1)-c1ccc(cc1)C(O)=O

InChI Key InChIKey=OKJCHFXBCVXSIZ-UHFFFAOYSA-N

Data  4 KI  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 210930   

TargetDihydrofolate reductase(Staphylococcus aureus)
University of Connecticut

LigandPNGBDBM210930(UCP1173)
Affinity DataIC50: 14nMAssay Description:IC50 values were determined following a standard method that has been described previously (Reeve et al., 2014, 2016).More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/31/2017
Entry Details Article
PubMed
TargetDihydrofolate reductase(Staphylococcus aureus)
University of Connecticut

LigandPNGBDBM210930(UCP1173)
Affinity DataIC50: 190nMAssay Description:IC50 values were determined following a standard method that has been described previously (Reeve et al., 2014, 2016).More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/31/2017
Entry Details Article
PubMed
TargetDihydrofolate reductase type 1 from Tn4003(Staphylococcus aureus)
University of Connecticut

LigandPNGBDBM210930(UCP1173)
Affinity DataIC50: 270nMAssay Description:IC50 values were determined following a standard method that has been described previously (Reeve et al., 2014, 2016).More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/31/2017
Entry Details Article
PubMed
TargetDihydrofolate reductase(Staphylococcus aureus)
University of Connecticut

LigandPNGBDBM210930(UCP1173)
Affinity DataIC50: 91nMAssay Description:IC50 values were determined following a standard method that has been described previously (Reeve et al., 2014, 2016).More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/31/2017
Entry Details Article
PubMed
TargetDihydrofolate reductase(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM210930(UCP1173)
Affinity DataIC50: 177nMAssay Description:Inhibition of Mycobacterium tuberculosis DHFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetDihydrofolate reductase(Escherichia coli)
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM210930(UCP1173)
Affinity DataKi:  0.910nMAssay Description:Inhibition of recombinant Escherichia coli DHFR expressed in Escherichia coli BL21(DE3) cells assessed as reduction in NADPH oxidation using dihydrof...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2017
Entry Details Article
PubMed
TargetDihydrofolate reductase(Staphylococcus aureus)
University of Connecticut

LigandPNGBDBM210930(UCP1173)
Affinity DataKi:  1.30nMAssay Description:Inhibition of recombinant Staphylococcus aureus DHFR expressed in Escherichia coli BL21(DE3) cells assessed as reduction in NADPH oxidation using dih...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2017
Entry Details Article
PubMed
TargetDihydrofolate reductase(Staphylococcus aureus)
University of Connecticut

LigandPNGBDBM210930(UCP1173)
Affinity DataKi:  1.30nMAssay Description:Inhibition of TMP/methicillin-resistant Staphylococcus aureus wild type DHFR assessed as oxidation of NADPH pre-incubated for 5 mins followed by dihy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM210930(UCP1173)
Affinity DataKi:  234nMAssay Description:Inhibition of recombinant human DHFR assessed as reduction in NADPH oxidation using dihydrofolate as substrate preincubated for 5 mins followed by su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2017
Entry Details Article
PubMed