BDBM50280450 18-hydroxy-3-methoxy-2-methyl-4-methylamino-(2R,3S,4S,6S)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.12,6.07,28.08,13.015,19.020,27.021,26]nonacosa-8(13),9,11,14(28),15(19),20(27),21(26),22,24-nonaen-16-one::CHEMBL574737::UCN-01::UCN-02

SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4[C@H](O)NC(=O)c4c4c5ccccc5n2c4c13

InChI Key InChIKey=PBCZSGKMGDDXIJ-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50280450   

TargetSerine/threonine-protein kinase Chk1(Human)
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50280450(UCN-01 | 18-hydroxy-3-methoxy-2-methyl-4-methylami...)
Affinity DataIC50: 10nMAssay Description:Inhibition of CHK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50280450(UCN-01 | 18-hydroxy-3-methoxy-2-methyl-4-methylami...)
Affinity DataIC50: 5.60nMAssay Description:Inhibition of human recombinant Chk1More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk2(Human)
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50280450(UCN-01 | 18-hydroxy-3-methoxy-2-methyl-4-methylami...)
Affinity DataIC50: 10nMAssay Description:Inhibition of CHK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
LigandPNGBDBM50280450(UCN-01 | 18-hydroxy-3-methoxy-2-methyl-4-methylami...)
Affinity DataIC50: 250nMAssay Description:Inhibition of protein kinase AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/17/2018
Entry Details

LigandPNGBDBM50280450(UCN-01 | 18-hydroxy-3-methoxy-2-methyl-4-methylami...)
Affinity DataIC50: 62nMAssay Description:Inhibition of protein kinase CMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/17/2018
Entry Details

LigandPNGBDBM50280450(UCN-01 | 18-hydroxy-3-methoxy-2-methyl-4-methylami...)
Affinity DataIC50: 250nMAssay Description:Inhibition of protein kinase AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/17/2018
Entry Details

LigandPNGBDBM50280450(UCN-01 | 18-hydroxy-3-methoxy-2-methyl-4-methylami...)
Affinity DataIC50: 62nMAssay Description:Inhibition of protein kinase CMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/17/2018
Entry Details

LigandPNGBDBM50280450(UCN-01 | 18-hydroxy-3-methoxy-2-methyl-4-methylami...)
Affinity DataIC50: 30nMAssay Description:Inhibition of CDK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article