BDBM50072147 (2Z,3Z)-2,3-bis(amino(2-aminophenylthio)methylene)succinonitrile::1,4-diamino-2,3-dicyano-1,4-bis(2-aminophenylthio)butadiene::1,4-diamino-2,3-dicyano-1,4-bis[2-aminophenylthio]butadiene monoethanolate::2,3-Bis-[1-amino-1-(2-amino-phenylsulfanyl)-meth-(Z)-ylidene]-succinonitrile::2,3-Bis-[amino-(2-amino-phenylsulfanyl)-methylene]-succinonitrile::2,3-bis(amino(2-aminophenylthio)methylene)succinonitrile::2-[1-Amino-1-(2-amino-phenylsulfanyl)-meth-(Z)-ylidene]-3-[1-amino-1-(2-amino-phenylsulfanyl)-meth-(E)-ylidene]-succinonitrile::2-[Amino-(2-amino-phenylsulfanyl)-methylene]-3-[1-amino-1-(2-amino-phenylsulfanyl)-meth-(Z)-ylidene]-succinonitrile::CHEMBL100473::CHEMBL95758::U-0126

SMILES Nc1ccccc1SC(=N)C(C#N)C(C#N)C(=N)Sc1ccccc1N

InChI Key InChIKey=ZCHZSBUNJOCWCW-UHFFFAOYSA-N

Data  27 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 27 hits for monomerid = 50072147   

TargetRAC-alpha serine/threonine-protein kinase(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50072147(CHEMBL100473 | 2,3-Bis-[1-amino-1-(2-amino-phenyls...)
Affinity DataIC50: 6.00E+4nMAssay Description:Inhibition of human PKBalpha expressed in SF9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2011
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 2(Human)
Complutense University of Madrid

Curated by ChEMBL
LigandPNGBDBM50072147(CHEMBL100473 | 2,3-Bis-[1-amino-1-(2-amino-phenyls...)
Affinity DataIC50: 58nMAssay Description:Inhibition of MEK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Complutense University of Madrid

Curated by ChEMBL
LigandPNGBDBM50072147(CHEMBL100473 | 2,3-Bis-[1-amino-1-(2-amino-phenyls...)
Affinity DataIC50: 72nMAssay Description:Inhibition of MEK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 2(Human)
Complutense University of Madrid

Curated by ChEMBL
LigandPNGBDBM50072147(CHEMBL100473 | 2,3-Bis-[1-amino-1-(2-amino-phenyls...)
Affinity DataIC50: 58nMAssay Description:Inhibition of MEK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Complutense University of Madrid

Curated by ChEMBL
LigandPNGBDBM50072147(CHEMBL100473 | 2,3-Bis-[1-amino-1-(2-amino-phenyls...)
Affinity DataIC50: 72nMAssay Description:Inhibition of MEK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Complutense University of Madrid

Curated by ChEMBL
LigandPNGBDBM50072147(CHEMBL100473 | 2,3-Bis-[1-amino-1-(2-amino-phenyls...)
Affinity DataIC50: 89nMAssay Description:Inhibition of recombinant full length human N-terminal GST-tagged C-terminal His6-tagged MEK1 expressed in Escherichia coli using myelin basic protei...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
LigandPNGBDBM50072147(CHEMBL100473 | 2,3-Bis-[1-amino-1-(2-amino-phenyls...)
Affinity DataIC50: 290nMAssay Description:Inhibition of EGF-stimulated Elk1-luciferase reporter assay in HeLa cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetMalate dehydrogenase(Thermus thermophilus)
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50072147(CHEMBL100473 | 2,3-Bis-[1-amino-1-(2-amino-phenyls...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibitory activity against malate dehydrogenase (MDH) from Thermus flavusMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetMAP kinase-activated protein kinase 5(Human)
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50072147(CHEMBL100473 | 2,3-Bis-[1-amino-1-(2-amino-phenyls...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of p38-regulated activated kinase (Protein kinase PRAK)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetChymotrypsinogen B(Human)
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50072147(CHEMBL100473 | 2,3-Bis-[1-amino-1-(2-amino-phenyls...)
Affinity DataIC50: 1.20E+5nMAssay Description:Inhibitory activity against Chymotrypsinogen from Thermus flavusMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetMAP kinase-activated protein kinase 5(Human)
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50072147(CHEMBL100473 | 2,3-Bis-[1-amino-1-(2-amino-phenyls...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of His-tagged human PRAK expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Peking University Health Science Center

Curated by ChEMBL
LigandPNGBDBM50072147(CHEMBL100473 | 2,3-Bis-[1-amino-1-(2-amino-phenyls...)
Affinity DataIC50: 250nMAssay Description:Inhibition of N-terminal GST-tagged human BRAF/MEK1/RAF1 Y340D/Y341D double mutant measured after 2 hrs in presence of ATP by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2017
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Complutense University of Madrid

Curated by ChEMBL
LigandPNGBDBM50072147(CHEMBL100473 | 2,3-Bis-[1-amino-1-(2-amino-phenyls...)
Affinity DataIC50: 1.30E+4nMAssay Description:Inhibition of Mitogen activated protein kinase kinase 1 (MKK1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50072147(CHEMBL100473 | 2,3-Bis-[1-amino-1-(2-amino-phenyls...)
Affinity DataIC50: 5.50E+4nMAssay Description:Inhibition of His-tagged human SAPK2a/p38 expressed in Escherichia coliMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2011
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1/2(Human)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50072147(CHEMBL100473 | 2,3-Bis-[1-amino-1-(2-amino-phenyls...)
Affinity DataIC50: 300nMAssay Description:AP-1 suppression activity using one month old DMSO stockMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/29/2012
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Complutense University of Madrid

Curated by ChEMBL
LigandPNGBDBM50072147(CHEMBL100473 | 2,3-Bis-[1-amino-1-(2-amino-phenyls...)
Affinity DataIC50: 72nMAssay Description:Inhibition of MEK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 2(Human)
Complutense University of Madrid

Curated by ChEMBL
LigandPNGBDBM50072147(CHEMBL100473 | 2,3-Bis-[1-amino-1-(2-amino-phenyls...)
Affinity DataIC50: 58nMAssay Description:Inhibition of MEK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Complutense University of Madrid

Curated by ChEMBL
LigandPNGBDBM50072147(CHEMBL100473 | 2,3-Bis-[1-amino-1-(2-amino-phenyls...)
Affinity DataIC50: 70nMAssay Description:Inhibitory potency against mitogen activated protein kinase kinase 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1/2(Human)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50072147(CHEMBL100473 | 2,3-Bis-[1-amino-1-(2-amino-phenyls...)
Affinity DataIC50: 500nMAssay Description:AP-1 suppression activity using two months old DMSO stockMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/29/2012
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 2(Human)
Complutense University of Madrid

Curated by ChEMBL
LigandPNGBDBM50072147(CHEMBL100473 | 2,3-Bis-[1-amino-1-(2-amino-phenyls...)
Affinity DataIC50: 60nMAssay Description:Inhibition of the dual specificity kinase MEK-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/29/2012
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Complutense University of Madrid

Curated by ChEMBL
LigandPNGBDBM50072147(CHEMBL100473 | 2,3-Bis-[1-amino-1-(2-amino-phenyls...)
Affinity DataIC50: 500nMAssay Description:Inhibition of the dual specificity kinase MEK-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/29/2012
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1/2(Human)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50072147(CHEMBL100473 | 2,3-Bis-[1-amino-1-(2-amino-phenyls...)
Affinity DataIC50: 300nMAssay Description:AP-1 suppression activity using one week old DMSO stockMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/29/2012
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Complutense University of Madrid

Curated by ChEMBL
LigandPNGBDBM50072147(CHEMBL100473 | 2,3-Bis-[1-amino-1-(2-amino-phenyls...)
Affinity DataIC50: 70nMAssay Description:Inhibition of the dual specificity kinase MEK-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/29/2012
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1/2(Human)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50072147(CHEMBL100473 | 2,3-Bis-[1-amino-1-(2-amino-phenyls...)
Affinity DataIC50: 2.48E+4nMAssay Description:AP-1 suppression activity using six months old DMSO stockMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/29/2012
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Complutense University of Madrid

Curated by ChEMBL
LigandPNGBDBM50072147(CHEMBL100473 | 2,3-Bis-[1-amino-1-(2-amino-phenyls...)
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibition of the dual specificity kinase MEK-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/29/2012
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1/2(Human)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50072147(CHEMBL100473 | 2,3-Bis-[1-amino-1-(2-amino-phenyls...)
Affinity DataIC50: 200nMAssay Description:AP-1 suppression activity using freshly prepared DMSO stockMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/29/2012
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1/2(Human)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50072147(CHEMBL100473 | 2,3-Bis-[1-amino-1-(2-amino-phenyls...)
Affinity DataIC50: 1.00E+3nMAssay Description:Ability to antagonise AP-1 transcriptional activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/29/2012
Entry Details Article
PubMed