BDBM50032951 5-(piperidin-4-yl)isothiazol-3-ol::5-Piperidin-4-yl-isothiazol-3-ol::CHEMBL109209::Thio-4-PIOL

SMILES O=c1cc(s[nH]1)C1CCNCC1

InChI Key InChIKey=WUINUICOEAZPLK-UHFFFAOYSA-N

Data  9 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50032951   

TargetGamma-aminobutyric acid type B receptor subunit 1/2(Rat)
Royal Danish School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50032951(Thio-4-PIOL | 5-Piperidin-4-yl-isothiazol-3-ol | C...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of Gamma-aminobutyric acid type B receptor of rat cortexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2012
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-5(Human)
Merck Sharp and Dohme Research Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM50032951(Thio-4-PIOL | 5-Piperidin-4-yl-isothiazol-3-ol | C...)
Affinity DataKi:  447nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/1/2012
Entry Details
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-2(Human)
Merck Sharp and Dohme Research Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM50032951(Thio-4-PIOL | 5-Piperidin-4-yl-isothiazol-3-ol | C...)
Affinity DataKi:  631nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/1/2012
Entry Details
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-3(Human)
Merck Sharp and Dohme Research Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM50032951(Thio-4-PIOL | 5-Piperidin-4-yl-isothiazol-3-ol | C...)
Affinity DataKi:  1.45E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/1/2012
Entry Details
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1(Human)
Merck Sharp and Dohme Research Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM50032951(Thio-4-PIOL | 5-Piperidin-4-yl-isothiazol-3-ol | C...)
Affinity DataKi:  1.70E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/1/2012
Entry Details
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1(Human)
Merck Sharp and Dohme Research Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM50032951(Thio-4-PIOL | 5-Piperidin-4-yl-isothiazol-3-ol | C...)
Affinity DataKi:  1.70E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/1/2012
Entry Details
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-6(Human)
Merck Sharp and Dohme Research Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM50032951(Thio-4-PIOL | 5-Piperidin-4-yl-isothiazol-3-ol | C...)
Affinity DataKi:  1.78E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/1/2012
Entry Details
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1(Human)
Merck Sharp and Dohme Research Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM50032951(Thio-4-PIOL | 5-Piperidin-4-yl-isothiazol-3-ol | C...)
Affinity DataKi:  3.63E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/1/2012
Entry Details
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1(Human)
Merck Sharp and Dohme Research Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM50032951(Thio-4-PIOL | 5-Piperidin-4-yl-isothiazol-3-ol | C...)
Affinity DataKi:  5.50E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/1/2012
Entry Details
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Human)
The Danish University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50032951(Thio-4-PIOL | 5-Piperidin-4-yl-isothiazol-3-ol | C...)
Affinity DataKi:  2.57E+4nMAssay Description:Binding affinity at human GABAA alpha-1-beta-3-gamma-2S expressed in Xenopus oocytes by voltage-clamp electrophysiologyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed