BDBM50209218 4',5,6,7,8-pentamethoxyflavone::5,6,7,8,4'-Pentamethoxyflavone::5,6,7,8-tetramethoxy-2-(4-methoxyphenyl)-4H-chromen-4-one::CHEMBL73930::Tangeretin

SMILES COc1ccc(cc1)-c1cc(=O)c2c(OC)c(OC)c(OC)c(OC)c2o1

InChI Key InChIKey=ULSUXBXHSYSGDT-UHFFFAOYSA-N

Data  2 KI  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50209218   

LigandPNGBDBM50209218(5,6,7,8-tetramethoxy-2-(4-methoxyphenyl)-4H-chrome...)
Affinity DataIC50: 1.70E+4nMAssay Description:Inhibition of BCRP expressed in MCF-7 MX cells using Hoechst 33342 stainingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
LigandPNGBDBM50209218(5,6,7,8-tetramethoxy-2-(4-methoxyphenyl)-4H-chrome...)
Affinity DataIC50: 1.90E+4nMAssay Description:Inhibition of BCRP expressed in MDCK cells using Hoechst 33342 stainingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50209218(5,6,7,8-tetramethoxy-2-(4-methoxyphenyl)-4H-chrome...)
Affinity DataIC50: 3.90E+4nMAssay Description:Inhibition of MDR1 expressed in MDCK cells using rhodamine 123 staining by flow cytometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetXanthine dehydrogenase/oxidase(Human)
University of Antwerp

Curated by ChEMBL
LigandPNGBDBM50209218(5,6,7,8-tetramethoxy-2-(4-methoxyphenyl)-4H-chrome...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of xanthine oxidase assessed as decrease in uric acid production by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
TargetUrease subunit beta(Helicobacter pylori (strain ATCC 700392 / 26695) (...)
Jishou University

Curated by ChEMBL
LigandPNGBDBM50209218(5,6,7,8-tetramethoxy-2-(4-methoxyphenyl)-4H-chrome...)
Affinity DataIC50: 4.63E+6nMAssay Description:Inhibition of Helicobacter pylori ATCC 43504 urease-mediated ammonia production preincubated for 1.5 hrs by indophenol methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetP2Y purinoceptor 2(Mouse)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM50209218(5,6,7,8-tetramethoxy-2-(4-methoxyphenyl)-4H-chrome...)
Affinity DataIC50: 1.20E+4nMAssay Description:Antagonist activity at mouse P2Y2More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetDelta-type opioid receptor(Mouse)
National Research Council

Curated by ChEMBL
LigandPNGBDBM50209218(5,6,7,8-tetramethoxy-2-(4-methoxyphenyl)-4H-chrome...)
Affinity DataKi:  7.00E+3nMAssay Description:Displacement of [3H]DPDPE from delta opioid receptor in CD1 mouse whole brain minus cerebellum membranes by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2016
Entry Details Article
PubMed
TargetMu-type opioid receptor(Mouse)
National Research Council

Curated by ChEMBL
LigandPNGBDBM50209218(5,6,7,8-tetramethoxy-2-(4-methoxyphenyl)-4H-chrome...)
Affinity DataKi:  1.63E+4nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor in CD1 mouse whole brain minus cerebellum membranes by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2016
Entry Details Article
PubMed